Rights statement: Electronic version of this article published as Nonequilibrium rate theory for conduction in open ion channels in Fluctuation and Noise Letters, Volume 11, Issue 1, 2012, 10 Pages DOI : 10.1142/S0219477512400160 © copyright World Scientific Publishing Company http://www.worldscientific.com/worldscinet/fnl
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Nonequilibrium rate theory for conduction in open ion channels
AU - Tindjong, R.
AU - Kaufman, I.
AU - McClintock, P. V. E.
AU - Luchinsky, D. G.
AU - Eisenberg, R. S.
N1 - Electronic version of this article published as Nonequilibrium rate theory for conduction in open ion channels in Fluctuation and Noise Letters, Volume 11, Issue 1, 2012, 10 Pages DOI : 10.1142/S0219477512400160 © copyright World Scientific Publishing Company http://www.worldscientific.com/worldscinet/fnl
PY - 2012/3/31
Y1 - 2012/3/31
N2 - We present a nonequilibrium reaction rate model of the ionic transition through an open ion channel, taking account of the interaction between an ion at the entrance of the channel and an ion at the binding site in a self-consistent way. The electrostatic potential is calculated by solution of the Poisson equation for a channel modeled as a cylindrical tube. The transition rate, and the binding site occupancy as a function of the left bulk concentration are compared to 1D Brownian dynamics simulations. The analysis is performed for a single binding site of high-affinity, with the exit rate influenced by barrier fluctuations at the channel exit. The results are compared with experimental data for the permeation of the Na+ ion through the Gramicidin A channel, with which they are shown to be in good agreement.
AB - We present a nonequilibrium reaction rate model of the ionic transition through an open ion channel, taking account of the interaction between an ion at the entrance of the channel and an ion at the binding site in a self-consistent way. The electrostatic potential is calculated by solution of the Poisson equation for a channel modeled as a cylindrical tube. The transition rate, and the binding site occupancy as a function of the left bulk concentration are compared to 1D Brownian dynamics simulations. The analysis is performed for a single binding site of high-affinity, with the exit rate influenced by barrier fluctuations at the channel exit. The results are compared with experimental data for the permeation of the Na+ ion through the Gramicidin A channel, with which they are shown to be in good agreement.
KW - Ion channels
KW - permeation
KW - nonequilibrium rate
KW - stochastic dynamics
KW - fluctuating barrier
U2 - 10.1142/S0219477512400160
DO - 10.1142/S0219477512400160
M3 - Journal article
VL - 11
JO - Fluctuation and Noise Letters
JF - Fluctuation and Noise Letters
SN - 0219-4775
IS - 1
M1 - 1240016
ER -