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Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel

Research output: Contribution to journalJournal articlepeer-review

Published
Article number1940007
<mark>Journal publication date</mark>1/06/2019
<mark>Journal</mark>Fluctuation and Noise Letters
Issue number2
Volume18
Number of pages13
Publication StatusPublished
Early online date1/04/19
<mark>Original language</mark>English

Abstract

The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.