Final published version, 3.32 MB, PDF document
Available under license: CC BY: Creative Commons Attribution 4.0 International License
Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Article number | 1940007 |
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<mark>Journal publication date</mark> | 1/06/2019 |
<mark>Journal</mark> | Fluctuation and Noise Letters |
Issue number | 2 |
Volume | 18 |
Number of pages | 13 |
Publication Status | Published |
Early online date | 1/04/19 |
<mark>Original language</mark> | English |
The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.