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Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel

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Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel. / Gibby, William Alexander Thomas; Barabash, Miraslau; Guardiani, Carlo et al.
In: Fluctuation and Noise Letters, Vol. 18, No. 2, 1940007, 01.06.2019.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gibby, WAT, Barabash, M, Guardiani, C, Luchinsky, D, Fedorenko, O, Roberts, SK & McClintock, PVE 2019, 'Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel', Fluctuation and Noise Letters, vol. 18, no. 2, 1940007. https://doi.org/10.1142/S0219477519400078

APA

Gibby, W. A. T., Barabash, M., Guardiani, C., Luchinsky, D., Fedorenko, O., Roberts, S. K., & McClintock, P. V. E. (2019). Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel. Fluctuation and Noise Letters, 18(2), Article 1940007. https://doi.org/10.1142/S0219477519400078

Vancouver

Gibby WAT, Barabash M, Guardiani C, Luchinsky D, Fedorenko O, Roberts SK et al. Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel. Fluctuation and Noise Letters. 2019 Jun 1;18(2):1940007. Epub 2019 Apr 1. doi: 10.1142/S0219477519400078

Author

Gibby, William Alexander Thomas ; Barabash, Miraslau ; Guardiani, Carlo et al. / Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel. In: Fluctuation and Noise Letters. 2019 ; Vol. 18, No. 2.

Bibtex

@article{cce8e9f8debc4ee3a2031a4a4cb2bcbd,
title = "Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel",
abstract = "The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.",
author = "Gibby, {William Alexander Thomas} and Miraslau Barabash and Carlo Guardiani and Dmitry Luchinsky and Olena Fedorenko and Roberts, {Stephen Kenneth} and McClintock, {Peter Vaughan Elsmere}",
year = "2019",
month = jun,
day = "1",
doi = "10.1142/S0219477519400078",
language = "English",
volume = "18",
journal = "Fluctuation and Noise Letters",
issn = "0219-4775",
publisher = "World Scientific Publishing Co. Pte Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel

AU - Gibby, William Alexander Thomas

AU - Barabash, Miraslau

AU - Guardiani, Carlo

AU - Luchinsky, Dmitry

AU - Fedorenko, Olena

AU - Roberts, Stephen Kenneth

AU - McClintock, Peter Vaughan Elsmere

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.

AB - The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.

U2 - 10.1142/S0219477519400078

DO - 10.1142/S0219477519400078

M3 - Journal article

VL - 18

JO - Fluctuation and Noise Letters

JF - Fluctuation and Noise Letters

SN - 0219-4775

IS - 2

M1 - 1940007

ER -