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Biomedical and Life Sciences

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  1. 2018
  2. Published

    Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

    Soares, P., Gadd, M. S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K. D. & Ciulli, A., 25/01/2018, In: Journal of Medicinal Chemistry. 61, 2, p. 599-618 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe

    Margalef, P., Kotsantis, P., Borel, V., Bellelli, R., Panier, S. & Boulton, S. J., 25/01/2018, In: Cell. 172, 3, p. 439-453 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Leishmania proteophosphoglycans regurgitated from infected sand flies accelerate dermal wound repair and exacerbate leishmaniasis via insulin-like growth factor 1-dependent signalling

    Giraud, E., Lěstinová, T., Derrick, T., Martin, O., Dillon, R. J., Volf, P., Műller, I., Bates, P. A. & Rogers, M. E., 19/01/2018, In: PLoS Pathogens. 14, 1, 31 p., e1006794.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Antibody response to sand fly saliva is a marker of transmission intensity but not disease progression in dogs naturally infected with Leishmania infantum

    Quinnell, R. J., Soremekun, S., Bates, P. A., Rogers, M. E., Garcez, L. M. & Courtenay, O., 4/01/2018, In: Parasites and Vectors. 11, 1, 12 p., 7.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Direct and indirect approaches to identify drug modes of action

    Tulloch, L. B., Menzies, S. K., Coron, R. P., Florence, G. J. & Smith, T. K., 1/01/2018, In: IUBMB Life. 70, 1, p. 9-22 14 p.

    Research output: Contribution to Journal/Magazine › Review article › peer-review

  7. Published

    Modelling the helium plasma jet delivery of reactive species into a 3D cancer tumour

    Szili, E. J., Oh, J. S., Fukuhara, H., Bhatia, R., Gaur, N., Nguyen, C. K., Hong, S. H., Ito, S., Ogawa, K., Kawada, C., Shuin, T., Tsuda, M., Furihata, M., Kurabayashi, A., Furuta, H., Ito, M., Inoue, K., Hatta, A. & Short, R. D., 1/01/2018, In: Plasma Sources Science and Technology. 27, 1, 16 p., 014001.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

    Tai, J., Liu, W., Li, Y., Li, L. & Hölscher, C., 1/01/2018, In: Brain Research. 1678, p. 64-74 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

    Worthington, J. J., Reimann, F. & Gribble, F. M., 01/2018, In: Mucosal Immunology. 11, p. 3-20 18 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Antimicrobial activity in cultures of female Drosophila Melanogaster

    Dwarampudi, V., 2018, Lancaster University. 201 p.

    Research output: Thesis › Master's Thesis

  11. Published

    Characterisation of non-essential genes required for survival under conditions of DNA stress

    Ahmed Ezzat, H., 2018, Lancaster University. 353 p.

    Research output: Thesis › Doctoral Thesis

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