Small molecule inhibitors of Aβ-aggregation and neurotoxicity

Hawkes, C. A., Ng, V. & McLaurin, J., 1/03/2009, In: Drug Development Research. 70, 2, p. 111-124 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy

Hawkes, C. A. & McLaurin, J., 27/01/2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 4, p. 1261-1266 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains

Amritraj, A., Hawkes, C., Phinney, A. L., Mount, H. T., Scott, C. D., Westaway, D. & Kar, S., 1/01/2009, In: Neurobiology of Aging. 30, 1, p. 54-70 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Clinical immunotherapy trials in Alzheimer's disease

Hawkes, C. A. & McLaurin, J. A., 1/09/2008, In: Drug Discovery Today: Therapeutic Strategies. 5, 3, p. 177-183 7 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation

Sun, Y., Zhang, G., Hawkes, C. A., Shaw, J. E., McLaurin, J. A. & Nitz, M., 1/08/2008, In: Bioorganic and Medicinal Chemistry. 16, 15, p. 7177-7184 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria

Lovegrove, F. E., Gharib, S. A., Patel, S. N., Hawkes, C. A., Kain, K. C. & Liles, W. C., 1/12/2007, In: American Journal of Pathology. 171, 6, p. 1894-1903 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Immunotherapy as treatment for Alzheimer's disease

Hawkes, C. A. & McLaurin, J., 1/11/2007, In: Expert Review of Neurotherapeutics. 7, 11, p. 1535-1548 14 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Heterotrimeric G proteins and the single-transmembrane domain IGF-II/M6P receptor: Functional interaction and relevance to cell signaling

Hawkes, C., Amritraj, A., MacDonald, R. G., Jhamandas, J. H. & Kar, S., 1/06/2007, In: Molecular Neurobiology. 35, 3, p. 329-345 17 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Effect of kainic acid treatment on insulin-like growth factor-2 receptors in the IGF2-deficient adult mouse brain

Dikkes, P., Hawkes, C., Kar, S. & Lopez, M. F., 2/02/2007, In: Brain Research. 1131, 1, p. 77-87 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal-lysosomal markers in surviving neurons after 192-IgG-saporin administrations into the adult rat brain

Hawkes, C., Kabogo, D., Amritraj, A. & Kar, S., 1/10/2006, In: American Journal of Pathology. 169, 4, p. 1140-1154 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

McLaurin, J. A., Kierstead, M. E., Brown, M. E., Hawkes, C. A., Lambermon, M. H. L., Phinney, A. L., Darabie, A. A., Cousins, J. E., French, J. E., Lan, M. F., Chen, F., Wong, S. S. N., Mount, H. T. J., Fraser, P. E., Westaway, D. & George-Hyslop, P. S., 1/07/2006, In: Nature Medicine. 12, 7, p. 801-808 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3β

Li, T., Hawkes, C., Qureshi, H. Y., Kar, S. & Paudel, H. K., 1/03/2006, In: Biochemistry. 45, 10, p. 3134-3145 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cellular distribution of insulin-like growth factor-II/mannose-6-phosphate receptor in normal human brain and its alteration in Alzheimer's disease pathology

Kar, S., Poirier, J., Guevara, J., Dea, D., Hawkes, C., Robitaille, Y. & Quirion, R., 1/02/2006, In: Neurobiology of Aging. 27, 2, p. 199-210 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Single transmembrane domain insulin-like growth factor-II/mannose-6- phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway

Hawkes, C., Jhamandas, J. H., Harris, K. H., Fu, W., MacDonald, R. G. & Kar, S., 11/01/2006, In: Journal of Neuroscience. 26, 2, p. 585-596 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin is associated with decreased phosphorylation of Ser9 glycogen synthase kinase-3β

Hawkes, C., Jhamandas, J. H. & Kar, S., 1/10/2005, In: Journal of Neurochemistry. 95, 1, p. 263-272 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The insulin-like growth factor-II/mannose-6-phosphate receptor: Structure, distribution and function in the central nervous system

Hawkes, C. & Kar, S., 1/03/2004, In: Brain Research Reviews. 44, 2-3, p. 117-140 24 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Insulin-like growth factor-II/mannose-6-phosphate receptor: Widespread distribution in neurons of the central nervous system including those expressing cholinergic phenotype

Hawkes, C. & Kar, S., 31/03/2003, In: Journal of Comparative Neurology. 458, 2, p. 113-127 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Insulin-like growth factor-II/mannose-6-phosphate receptor in the spinal cord and dorsal root ganglia of the adult rat

Hawkes, C. & Kar, S., 31/01/2002, In: European Journal of Neuroscience. 15, 1, p. 33-39 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review