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Research

Dr Edward Parkin

Senior Lecturer in Biomedicine

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  1. Published

    Herpes simplex virus interferes with amyloid precursor protein processing.

    Shipley, S. J., Parkin, E. T., Itzhaki, R. F. & Dobson, C. B., 18/08/2005, In: BMC Microbiology. 5, p. 48

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders.

    Isaac, R. E., Parkin, E. T., Keen, J. N., Nässel, D. R., Siviter, R. J. & Shirras, A. D., 04/2002, In: Peptides. 23, 4, p. 725-733 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Isolation and characterization of two distinct low-density, Triton-insoluble, complexes from porcine lung membranes

    Parkin, E., Turner, A. J. & Hooper, N. M., 1996, In: Biochemical Journal. 319 , 3, p. 887-896 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis

    Wilkinson, D. K., Turner, E. J., Parkin, E. T., Garner, A. E., Harrison, P. J., Crawford, M., Stewart, G. W. & Hooper, N. M., 01/2008, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778, 1, p. 125-132 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Modulation of phosphatidylcholine biosynthesis in celery by exogenous fatty acids.

    Parkin, E. T. & Rolphe, C. E., 15/01/1999, In: Phytochemistry. 50, 1, p. 47-51 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Notch Signalling as a Therapeutic Target in Cancer

    Martinas, I. & Parkin, E. T., 10/2016, In: International Journal of Cancer Therapy and Oncology. 4, 4

    Research output: Contribution to Journal/Magazine › Literature review › peer-review

  7. Published

    Osteonectin as a screening marker for pancreatic cancer: A prospective study

    Papapanagiotou, A., Sgourakis, G., Karkoulias, K., Raptis, D., Parkin, E. T., Brotzakis, P., Panchal, S. & Papavassiliou, A., 1/07/2018, In: Journal of International Medical Research. 46, 7, p. 2769-2779 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Phoshatidylcholine biosynthesis and cell growth in Apium graveolens

    Parkin, E. & Rolph, C., 08/1995, In: Physiologia Plantarum. 94, 4, p. 643-650 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. E-pub ahead of print

    Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease

    Armstrong, P., Güngör, H., Anongjanya, P., Tweedy, C., Parkin, E., Johnston, J., Carr, I. M., Dawson, N. & Clapcote, S. J., 23/03/2024, (E-pub ahead of print) In: Neuropsychopharmacology.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Pyruvate dehydrogenase kinase inhibition: reversing the Warburg effect in cancer therapy

    Bell, H. & Parkin, E. T., 23/06/2016, In: International Journal of Cancer Therapy and Oncology. 4, 2, p. 4215-4227 12 p.

    Research output: Contribution to Journal/Magazine › Literature review › peer-review

  11. Published

    Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein

    Taylor, D. R., Parkin, E. T., Cocklin, S. L., Ault, J. R., Ashcroft, A. E., Turner, A. J. & Hooper, N. M., 21/08/2009, In: Journal of Biological Chemistry. 284, 34, p. 22590-22600 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Secretase-mediated cell surface shedding of the angiotensin-converting enzyme.

    Parkin, E. T., Turner, A. J. & Hooper, N. M., 2004, In: Protein and Peptide Letters. 11, p. 423-432 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration: disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling

    Delury, C. P., Hart, C., Brown, M., Clarke, N. & Parkin, E. T., 25/03/2016, In: Biochemical and Biophysical Research Communications. 472, 1, p. 255-261 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Structure-Activity Relationship of Hydroxamate-Based Inhibitors on the Secretases that Cleave the Amyloid Precursor Protein, Angiotensin Converting Enzyme, CD23, and Pro-Tumor Necrosis Factor.

    Parkin, E. T., Trew, A., Christie, G., Faller, A., Mayer, R., Turner, A. J. & Hooper, N. M., 16/04/2002, In: Biochemistry. 41, 15, p. 4972-4981 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Studies on CTP: Cholinephosphate cytidylyltransferase in Apium graveolens

    Parkin, E. T., Goad, J. L. & Rolph, C. E., 1/05/1993, In: Biochemical Society Transactions. 21, 2, p. 77S

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein

    Harris, B., Pereira, I. & Parkin, E., 16/10/2009, In: Brain Research. 1296, n/a, p. 203-215 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    The Alzheimer's amyloid precursor protein a-secretase and the angiotensin converting enzyme secretase exhibit closely related enzyme activities.

    Parkin, E. T., Turner, A. J. & Hooper, N. M., 2000.

    Research output: Contribution to conference - Without ISBN/ISSN › Other

  18. Published

    The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains

    Parkin, E., Hussain, I., Turner, A. J. & Hooper, N. M., 11/1997, In: Journal of Neurochemistry. 69, 5, p. 2179-2188 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    The Amyloid Precursor Protein Plays Differential Roles in the UVA Resistance and Proliferation of Human Retinal Pigment Epithelial Cells

    Sultan, F. & Parkin, E., 30/03/2022, In: Protein and Peptide Letters. 29, 4, p. 313-327 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines

    Hicks, D. A., Makova, N. Z., Gough, M., Parkin, E. T., Nalivaeva, N. N. & Turner, A. J., 6/09/2013, In: Journal of Biological Chemistry. 288, 36, p. 26039-26051 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

    Gough, M., Blanthorn-Hazell, S., Delury, C. & Parkin, E., 31/10/2014, In: Biochemical and Biophysical Research Communications. 453, 4, p. 741-747 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    The E1 copper binding domain of full-length amyloid precursor protein promotes epithelial to mesenchymal transition in DU145 cells in isoform-specific manner

    Gough, M., Delury, C. & Parkin, E., 2015, In: International Journal of Biochemistry Research and Review. 6, 1, p. 264-273 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.

    Parkin, E. T., Tan, F., Skidgel, R. A., Turner, A. J. & Hooper, N. M., 1/08/2003, In: Journal of Cell Science. 116, 15, p. 3079-3087 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease

    Gough, M., Blanthorn-Hazell, S. & Parkin, E. T., 2015, In: Journal of Alzheimer's Disease. 43, 4, p. 1163-1168 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein

    Parkin, E. T., Hammond, J. E., Owens, L. & Hodges, M. D., 13/01/2022, In: PLoS ONE. 17, 1, 21 p., e0255715.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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