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Professor John Whitehead

Emeritus

  1. 2021
  2. Published

    Mycophenolate Mofetil Versus Cyclophosphamide for Remission Induction in Childhood Polyarteritis Nodosa: An Open-Label, Randomized, Bayesian Noninferiority Trial

    Brogan, P. A., Arch, B., Hickey, H., Anton, J., Iglesias, E., Baildam, E., Mahmood, K., Cleary, G., Moraitis, E., Papadopoulou, C., Beresford, M. W., Riley, P., Demir, S., Ozen, S., Culeddu, G., Hughes, D. A., Dolezalova, P., Hampson, L., Whitehead, J., Jayne, D. & 3 others, Ruperto, N., Tudur-Smith, C. & Eleftheriou, D., 30/09/2021, In: Arthritis and Rheumatology. 73, 9, p. 1673-1682 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  3. Published

    On the Unreliability of Multiple Systems Estimation for Estimating the Number of Potential Victims of Modern Slavery in the UK

    Whitehead, J., Jackson, J., Balch, A. & Francis, B., 2/01/2021, In: Journal of Human Trafficking. 7, 1, p. 1-13 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  4. 2020
  5. E-pub ahead of print

    Whitehead et al. Response to “Misunderstandings of Multiple Systems Estimation.”

    Whitehead, J., Jackson, J., Balch, A. & Francis, B., 6/11/2020, (E-pub ahead of print) In: Journal of Human Trafficking. 5 p.

    Research output: Contribution to Journal/MagazineComment/debatepeer-review

  6. Published

    Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19

    Stallard, N., Hampson, L., Benda, N., Brannath, W., Burnett, T., Friede, T., Kimani, P. K., Koenig, F., Krisam, J., Mozgunov, P., Posch, M., Wason, J., Wassmer, G., Whitehead, J., Williamson, S. F., Zohar, S. & Jaki, T., 1/10/2020, In: Statistics in Biopharmaceutical Research. 12, 4, p. 483-497 15 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. Published

    Estimation of treatment effects following a sequential trial of multiple treatments

    Whitehead, J., Desai, Y. & Jaki, T., 20/05/2020, In: Statistics in Medicine. 39, 11, p. 1593-1609 17 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  8. 2016
  9. Published

    Experimental treatment of Ebola virus disease with Brincidofovir

    Rapide-BCV trial team, 9/09/2016, In: PLoS ONE. 11, 9, 10 p., e162199.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  10. Published

    A comparison of the barely Bayesian design with the triangular test for clinical trials in infectious diseases

    Whitehead, J. R., 08/2016, In: Clinical Trials. 13, 4, p. 451-453 3 p.

    Research output: Contribution to Journal/MagazineLetterpeer-review

  11. Published

    Experimental treatment of Ebola virus disease with TKM-130803: a single-arm phase 2 clinical trial

    RAPIDE-TKM trial team, 19/04/2016, In: PLoS Medicine. 13, 4, 19 p., e1001997.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  12. Published

    Trial design for evaluating novel treatments during an outbreak of an infectious disease

    Whitehead, J. R., Olliaro, P., Lang, T. & Horby, P. W., 02/2016, In: Clinical Trials. 13, 1, p. 31-38 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  13. 2015
  14. Published

    Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol

    Arabi, Y., Balkhy, H., Hajeer, A. H., Bouchama, A., Hayden, F. G., Al-Omari, A., Al-Hameed, F. M., Taha, Y., Shindo, N., Whitehead, J. R., Merson, L., AlJohani, S., Al-Khairy, K., Carson, G., Luke, T. C., Hensley, L., Al-Dawood, A., Al-Qahtani, S., Modjarrad, K., Sadat, M. & 3 others, Rohde, G., Leport, C. & Fowler, R., 19/11/2015, In: SpringerPlus. 2015, 4, 8 p., 709.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  15. Published

    Bayesian adaptive dose-escalation procedures for binary and continuous responses utilizing a gain function

    Yeung, W. Y., Whitehead, J. R., Reigner, B., Beyer, U., Diack, C. & Jaki, T. F., 11/2015, In: Pharmaceutical Statistics. 14, 6, p. 479-487 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  16. Published

    Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of Telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy

    Pushpakom, S. P., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcıa-Finana, M., Kemp, G. J., Whitehead, J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/10/2015, In: BMJ Open. 5, 10, 13 p., e009566.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  17. Published

    Partial stochastic dominance for the multivariate Gaussian distribution

    Turner, A. & Whitehead, J., 08/2015, In: Statistics and Probability Letters. 103, p. 80-85 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  18. Published

    Bayesian sample sizes for exploratory clinical trials comparing multiple experimental treatments with a control

    Whitehead, J., Cleary, F. & Turner, A., 30/05/2015, In: Statistics in Medicine. 34, 12, p. 2048-2061 14 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  19. Published

    Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa

    Beresford, M. W., Bracaglia, C., Caldas, A., Cimaz, R., Dehoorne, J., Dolezalova, P., Friswell, M., Jelusic, M., Marks, S. D., Martin, N., McMahon, A-M., Peitz, J., van Royen-Kirkhof, A., Soylemezoglu, O., Brogan, P. & MYPAN Vasculitis Expert Group, 30/03/2015, In: PLoS ONE. 10, 3, 14 p., e0120981.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  20. 2014
  21. Published

    Bayesian methods for the design and interpretation of clinical trials in very rare diseases

    Hampson, L., Whitehead, J., Eleftheriou, D. & Brogan, P., 30/10/2014, In: Statistics in Medicine. 33, 24, p. 4186-4201 16 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  22. Published
  23. 2013
  24. Published

    Designing exploratory cancer trials using change in tumour size as primary endpoint

    Jaki, T., Andre, V., Su, T-L. & Whitehead, J., 10/07/2013, In: Statistics in Medicine. 32, 15, p. 2544-2554 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  25. 2012
  26. Published

    A bivariate Bayesian dose-finding procedure applied to a seamless phase I/II trial in rheumatoid arthritis

    Thygesen, H., Dragalin, V., Whitehead, A. & Whitehead, J., 11/2012, In: Pharmaceutical Statistics. 11, 6, p. 476-484 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  27. Published

    A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

    Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D., 15/08/2012, In: Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  28. Published

    A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

    Magirr, D., Jaki, T. & Whitehead, J., 06/2012, In: Biometrika. 99, 2, p. 494-501 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  29. 2011
  30. Published

    Bayesian procedures for phase I/II clinical trials investigating the safety and efficacy of drug combinations

    Whitehead, J., Thygesen, H. & Whitehead, A., 20/07/2011, In: Statistics in Medicine. 30, 16, p. 1952-1970 19 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  31. 2010
  32. Published

    A Bayesian dose-escalation procedure for phase I clinical trials based only on the assumption of monotonicity.

    Whitehead, J., Thygesen, H. & Whitehead, A., 30/07/2010, In: Statistics in Medicine. 29, 17, p. 1808-1824 17 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  33. Published

    A combined score test for binary and ordinal endpoints from clinical trials.

    Whitehead, J., Branson, M. & Todd, S., 28/02/2010, In: Statistics in Medicine. 29, 5, p. 521-532 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  34. 2009
  35. Published

    Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme.

    Whitehead, J., Kelly, P., Zhou, Y., Stallard, N., Thygesen, H. & Bowman, C., 10/2009, In: Pharmaceutical Statistics. 8, 4, p. 287-300 14 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  36. Published

    A simple two-stage design for quantitative responses with appliction to a study in diabectic neuropathic pain.

    Whitehead, J., Valdés-Márquez, E. & Lissmats, A., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 125-135 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  37. Published

    Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline.

    Bolland, K., Whitehead, J., Cobo, E. & Secades, J. J., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 136-149 14 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  38. Published

    Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke.

    Whitehead, J., Bolland, K., Valdés-Márquez, E., Lihic, A., Ali, M. & Lees, K., 04/2009, In: Stroke. 40, 4, p. 1347-1352 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  39. Published

    One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.

    Whitehead, J. & Jaki, T., 28/02/2009, In: Statistics in Medicine. 28, 5, p. 828-847 20 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  40. 2008
  41. Published

    Fitting models for the joint action of two drugs using SAS(R).

    Whitehead, A., Whitehead, J., Todd, S., Zhou, Y. & Smith, M. K., 10/2008, In: Pharmaceutical Statistics. 7, 4, p. 272-284 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  42. Published

    Estimation following selection of the largest of two normal means. Journal of Statistical Planning and Inference 138, 1629-1638.

    Stallard, N., Todd, S. & Whitehead, J., 1/07/2008, In: Journal of Statistical Planning and Inference. 138, 6, p. 1629-1638 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  43. Published

    A safety monitoring procesure for a clinical drug development programme, with application to the accessment of a novel COX-2 inhibitor.

    Bolland, K., Whitehead, J. & Oldham, M., 07/2008, In: Journal of Biopharmaceutical Statistics. 18, 4, p. 737-749 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  44. Published

    Bayesian sample size for exploratory clinical trials incorporating historical data.

    Whitehead, J., Valdés-Márquez, E., Johnson, P. & Graham, G., 06/2008, In: Statistics in Medicine. 27, 13, p. 2307-2327 21 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  45. Published

    Sequentially testing for a gene-drug interaction in a genomewide analysis.

    Kelly, P., Zhou, Y., Whitehead, J., Stallard, N. & Bowman, C., 20/05/2008, In: Statistics in Medicine. 27, 11, p. 2022-2034 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  46. Published

    Incorporating intermediate binary responses into interim analyses of clinical trials : a comparison of four methods.

    Whitehead, A., Sooriyarachchi, M. R., Whitehead, J. & Bolland, K., 10/05/2008, In: Statistics in Medicine. 27, 10, p. 1646-1666 21 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  47. Published

    Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers.

    Whitehead, J., Korhonen, P., Mustonen, M. & Zhou, Y., 03/2008, In: Biometrics. 64, 1, p. 299-308 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  48. 2007
  49. Published

    A Bayesian approach for dose-escalation in a phase I clinical trial incorporating pharmacodynamic endpoints .

    Whitehead, J., Hampson, L., Zhou, Y., Ledent, E. & Pereira, A., 11/2007, In: Journal of Biopharmaceutical Statistics. 17, 6, p. 1117-1129 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  50. 2006
  51. Published

    Sequential genome-wide association studies for monitoring adverse events in clinical evaluation of new drugs.

    Whitehead, J., Kelly, P. J., Stallard, N., Zhou, Y. & Bowman, C., 30/09/2006, In: Statistics in Medicine. 25, 18, p. 3081-3092 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  52. Published

    The sequential analysis of repeated binary responses: a score test for the case of three time points.

    Sooriyarachchi, M. R., Whitehead, J., Whitehead, A. & Bolland, K., 15/07/2006, In: Statistics in Medicine. 25, 13, p. 2196-2214 19 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  53. 2003
  54. Published

    Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods.

    Whitehead, J., Bollard, K., Matsushita, T., Sooriyarachchi, M. R. & Whitehead, A., 09/2003, In: Biometrics. 59, 3, p. 701-709 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  55. 2001
  56. Published

    Easy-to-implement Bayesian methods for dose-escalation studies in healthy volunteers.

    Whitehead, J., Patterson, S., Webber, D. & Zhou, Y., 03/2001, In: Biostatistics. 2, 1, p. 47-61 15 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  57. 1991
  58. Published

    Analysis of failure time data with ordinal categories of response

    Berridge, D. & Whitehead, J., 11/1991, In: Statistics in Medicine. 10, 11, p. 1703-1710 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  59. Published

    Mammographic dysplasia as entry criterion for breast cancer prevention trials

    Berridge, D., Whitehead, J. & Cuzick, J., 18/05/1991, In: The Lancet. 337, 8751, p. 1225 1 p.

    Research output: Contribution to Journal/MagazineLetterpeer-review

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