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Dr Leonie Unterholzner

Senior Lecturer

  1. 2003
  2. Published

    Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

    Gatfield, D., Unterholzner, L., Ciccarelli, F. D., Bork, P. & Izaurralde, E., 1/08/2003, In: EMBO Journal. 22, 15, p. 3960-3970 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. 2004
  4. Published

    Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex

    Bono, F., Ebert, J., Unterholzner, L., Güttler, T., Izaurralde, E. & Conti, E., 03/2004, In: EMBO Reports. 5, 3, p. 304-310 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

    Unterholzner, L. & Izaurralde, E., 19/11/2004, In: Molecular Cell. 16, 4, p. 587-596 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. 2005
  7. Published

    SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

    Fukuhara, N., Ebert, J., Unterholzner, L., Lindner, D., Izaurralde, E. & Conti, E., 18/02/2005, In: Molecular Cell. 17, 4, p. 537-547 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. 2008
  9. Published

    The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities

    Unterholzner, L. & Bowie, A. G., 1/02/2008, In: Biochemical Pharmacology. 75, 3, p. 589-602 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Viral evasion and subversion of pattern-recognition receptor signalling

    Bowie, A. G. & Unterholzner, L., 12/2008, In: Nature Immunology. 8, 12, p. 911-922 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. 2010
  12. Published

    IFI16 is an innate immune sensor for intracellular DNA

    Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., Fitzgerald, K. A., Paludan, S. R. & Bowie, A. G., 11/2010, In: Nature Immunology. 11, 11, p. 997-1004 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. 2011
  14. Published

    Innate DNA sensing moves to the nucleus

    Unterholzner, L. & Bowie, A. G., 19/05/2011, In: Cell Host and Microbe. 9, 5, p. 351-353 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7

    Unterholzner, L., Sumner, R. P., Baran, M., Ren, H., Mansur, D. S., Bourke, N. M., Randow, F., Smith, G. L. & Bowie, A. G., 09/2011, In: PLoS Pathogens. 7, 9, e1002247.

    Research output: Contribution to journalJournal articlepeer-review

  16. 2012
  17. Published

    Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor

    Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J. A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V. A., Johnstone, R. W., Hornung, V., Latz, E., Bowie, A. G., Fitzgerald, K. A. & Xiao, T. S., 20/04/2012, In: Immunity. 36, 4, p. 561-571 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. 2013
  19. Published

    Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

    Mansur, D. S., Maluquer de Motes, C., Unterholzner, L., Sumner, R. P., Ferguson, B. J., Ren, H., Strnadova, P., Bowie, A. G. & Smith, G. L., 02/2013, In: PLoS Pathogens. 9, 2, e1003183.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

    Horan, K. A., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A. G., Fitzgerald, K. A. & Paludan, S. R., 1/03/2013, In: Journal of Immunology. 190, 5, p. 2311-2319 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    The interferon response to intracellular DNA: why so many receptors?

    Unterholzner, L., 11/2013, In: Immunobiology. 218, 11, p. 1312-1321 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. 2017
  23. Published

    IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

    Almine, J. F., O'Hare, C. A. J., Dunphy, G., Haga, I. R., Naik, R. J., Atrih, A., Connolly, D. J., Taylor, J., Kelsall, I. R., Bowie, A. G., Beard, P. M. & Unterholzner, L., 13/02/2017, In: Nature Communications. 8, 14392.

    Research output: Contribution to journalJournal articlepeer-review

  24. 2018
  25. Published

    Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signalling after nuclear DNA damage

    Dunphy, G., Flannery, S., Almine, J., Connolly, D., Paulus, C., Jønsson, K., Jakobsen, M., Nevels, M., Bowie, A. & Unterholzner, L., 6/09/2018, In: Molecular Cell. 71, 5, p. 745-760 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. 2019
  27. Published

    Camouflage and interception: How pathogens evade detection by intracellular nucleic acid sensors

    Unterholzner, L. & Almine, J. F., 03/2019, In: Immunology. 156, 3, p. 217-227 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Beyond sensing DNA: A role for cGAS in the detection of extracellular cyclic di-nucleotides

    Unterholzner, L., 1/04/2019, In: EMBO Reports. 20, 4, e47970.

    Research output: Contribution to journalJournal article

  29. Published

    cGAS-independent STING activation in response to DNA damage

    Unterholzner, L. & Dunphy, G., 19/04/2019, In: Molecular & Cellular Oncology. 6, 4, 3 p., e1558682 .

    Research output: Contribution to journalJournal articlepeer-review

  30. 2021
  31. Published

    Structural mechanism of DNA recognition by the p204 HIN domain

    Fan, X., Jiang, J., Zhao, D., Chen, F., Ma, H., Smith, P., Unterholzner, L., Xiao, T. S. & Jin, T., 18/03/2021, In: Nucleic Acids Research. 49, 5, p. 2959-2972 14 p.

    Research output: Contribution to journalJournal articlepeer-review

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