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Research

Dr Shefeeq Theparambil

Lecturer in Neuroscience

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  1. 2025
  2. Published

    On the mechanisms of brain blood flow regulation during hypoxia

    Mascarenhas, A., Braga, A., Majernikova, S. M., Nizari, S., Marletta, D., Theparambil, S. M., Aziz, Q., Marina, N. & Gourine, A. V., 15/04/2025, In: The Journal of Physiology. 603, 8, p. 2263-2280 18 p.

    Research output: Contribution to Journal/Magazine › Review article › peer-review

  3. 2024
  4. Published

    Adenosine signalling to astrocytes coordinates brain metabolism and function

    Theparambil, S. M., Kopach, O., Braga, A., Nizari, S., Hosford, P. S., Sagi-Kiss, V., Hadjihambi, A., Konstantinou, C., Esteras, N., Gutierrez Del Arroyo, A., Ackland, G. L., Teschemacher, A. G., Dale, N., Eckle, T., Andrikopoulos, P., Rusakov, D. A., Kasparov, S. & Gourine, A. V., 1/08/2024, In: Nature. 632, 8023, p. 139-146 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain

    Theparambil, S. M., Begum, G. & Rose, C. R., 30/06/2024, In: Cell Calcium. 120, 102882.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. 2023
  7. Published

    Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia

    Christie, I. N., Theparambil, S. M., Braga, A., Doronin, M., Hosford, P. S., Brazhe, A., Mascarenhas, A., Nizari, S., Hadjihambi, A., Wells, J. A., Hobbs, A., Semyanov, A., Abramov, A. Y., Angelova, P. R. & Gourine, A. V., 26/12/2023, In: Cell Reports. 42, 12, 113514.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    The astrocytic Na+-HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity

    Gourine, A. & Theparambil, S., 15/09/2023, In: The Journal of Physiology. p. 4171-4172 2 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Salt-loading promotes extracellular ATP release mediated by glial cells in the hypothalamic paraventricular nucleus of rats

    Martins, S. R., Theparambil, S., Dos, S. K., Christie, I., Marina, N., Cardoso, B., Hosford, P. & Antunes, V., 31/03/2023, In: Molecular and cellular neurosciences. 124, 103806.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. 2022
  11. Published

    CO2 signaling mediates neurovascular coupling in the cerebral cortex

    Hosford, P., Wells, J., Nizari, S., Christie, I., Theparambil, S., Castro, P., Hadjihambi, A., Barros, L., Ruminot, I., Lythgoe, M. & Gourine, A., 19/04/2022, In: Nature Communications. 13, 2125.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. 2021
  13. Published

    Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke

    Nizari, S., Basalay, M., Chapman, P., Korte, N., Korsak, A., Christie, I. N., Theparambil, S., Davidson, S. M., Reimann, F., Trapp, S., Yellon, D. & Gourine, A., 3/05/2021, In: Basic research in cardiology. 116, 32.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. 2020
  15. Published

    Mechanosensory Signaling in Astrocytes.

    Turovsky, E., ALICE, B., Yu, Y., Esteras, N., Korsak, A., Theparambil, S., Hadjihambi, A., Hosford, P., Teschemacher, A., Marina, N., Lythgoe, M., Haydon, P. & Gourine, A., 2/12/2020, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 40, 49, p. 9364-9371

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle.

    Theparambil, S., Hosford, P., Ruminot, I., Kopach, O., Reynolds, J., Sandoval, P. Y., Rusakov, D. A., Barros, L. & Gourine, A., 8/10/2020, In: Nature Communications. 11, 5073.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    The effect of general anaesthetics on brain lactate release.

    Hadjihambi, A., Karagiannis, A., Theparambil, S., Gareth, L. A. P. F. F. F. & Gourine, A., 15/08/2020, In: European Journal of Pharmacology. 881, 173188.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Astrocytes Modulate Baroreflex Sensitivity at the Level of the Nucleus of the Solitary Tract.

    Mastitskaya, S., Turovsky, E., Marina, N., Theparambil, S., Hadjihambi, A., Kasparov, S., Teschemacher, A., Ramage, A., Gourine, A. & Hosford, P., 8/04/2020, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 40, 15, p. 3052-3062

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. 2019
  20. Published

    Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis.

    Deitmer, J., Theparambil, S., Ruminot, I., Noor, S. & Becker, H., 6/12/2019, In: Frontiers in Neuroscience. 13, 7 p., 1301.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255-257 and regulated by mTOR.

    Khakipoor, S., Giannaki, M., Theparambil, S., Zecha, J., Küster, B., Heermann, S., Deitmer, J. & Roussa, E., 1/12/2019, In: Glia. 67, 12, p. 2264-2278

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Cytosolic sodium regulation in mouse cortical astrocytes and its dependence on potassium and bicarbonate.

    Noor, Z., Deitmer, J. & Theparambil, S. M., 1/01/2019, In: Journal of Cellular Physiology. 234, 1, p. 89-99

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. 2018
  24. Published

    Brain metabolic sensing and metabolic signaling at the level of an astrocyte

    Marina, N., Turovsky, E., Christie, I. N., Hosford, P. S., Hadjihambi, A., Korsak, A., Ang, R., Mastitskaya, S., Sheikhbahaei, S., Theparambil, S. M. & Gourine, A. V., 30/06/2018, In: Glia. 66, 6, p. 1185-1199 15 p.

    Research output: Contribution to Journal/Magazine › Review article › peer-review

  25. Published

    Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity.

    SheikhBahaei, S., Turovsky, E., Hosford, P., Hadjihambi, A., Theparambil, S., Liu, B., Marina, N., Teschemacher, A., Kasparov, S., Smith, J. & Gourine, A., 25/01/2018, In: Nature Communications. 9, 370.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. 2017
  27. Published

    Bicarbonate sensing in mouse cortical astrocytes during extracellular acid/base disturbances.

    Theparambil, S., Naoshin, Z., Defren, S., Schmaelzle, J., Weber, T., Schneider, H. & Deitmer, J., 15/04/2017, In: The Journal of Physiology. 595, 8, p. 2569-2585

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. 2016
  29. Published

    Mechanisms of CO2/H+ Sensitivity of Astrocytes.

    Turovsky, E., Theparambil, S., Kasymov, V., Deitmer, J., Arroyo, A. G. D., Gareth, L. A. P. F. F. F., Corneveaux, J., Allen, A., Huentelman, M., Kasparov, S., Marina, N. & Gourine, A., 19/10/2016, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 36, 42, p. 10750-10758

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  30. Published

    Proton Fall or Bicarbonate Rise: GLYCOLYTIC RATE IN MOUSE ASTROCYTES IS PAVED BY INTRACELLULAR ALKALINIZATION.

    Theparambil, S., Weber, T., Schmälzle, J., Ruminot, I. & Deitmer, J., 2/09/2016, In: The Journal of biological chemistry. 291, 36, p. 19108-19117

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. 2015
  32. Published

    High effective cytosolic H+ buffering in mouse cortical astrocytes attributable to fast bicarbonate transport.

    Theparambil, S. & Deitmer, J., 1/09/2015, In: Glia. 63, 9, p. 1581-1594

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes.

    Theparambil, S., Naoshin, Z., Thyssen, A. & Deitmer, J., 15/08/2015, In: The Journal of Physiology. 593, 16, p. 3533-3547

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  34. Published

    Regulation of functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), in mouse astrocytes.

    Schrödl-Häußel, M., Theparambil, S., Deitmer, J. & Roussa, E., 1/07/2015, In: Glia. 63, 7, p. 1226-1239

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  35. Published

    The role of membrane acid/base transporters and carbonic anhydrases for cellular pH and metabolic processes.

    Deitmer, J., Theparambil, S., Ruminot, I. & Becker, H., 5/01/2015, In: Frontiers in Neuroscience. 8, 430.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  36. 2014
  37. Published

    The electrogenic sodium bicarbonate cotransporter NBCe1 is a high-affinity bicarbonate carrier in cortical astrocytes.

    Theparambil, S., Ruminot, I., Schneider, H., Shull, G. & Deitmer, J., 22/01/2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 4, p. 1148-1157

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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