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Research

Dr Steve Hall

Lecturer in Pharmacology

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  1. 2024
  2. Published

    Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

    Bartlett, K. E., Hall, S., Rasmussen, S. A., Crittenden, E., Dawson, C. A., Albulescu, L-O., Laprade, W., Harrison, R. A., Saviola, A. J., Modahl, C., Jenkins, T. P., Wilkinson, M. C., Gutiérrez, J. M. & Casewell, N. R., 7/05/2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 19, p. 1-12 12 p., e2315597121.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Editorial: Experimental and computational aspects of bioactive proteins from animal venoms: an insight into pharmacological properties and drug discovery

    Khai Khun Yap, M., Modahl, C. & Hall, S., 16/02/2024, In: Frontiers in Pharmacology. 15, p. 1-3 3 p.

    Research output: Contribution to Journal/Magazine › Editorial

  4. 2023
  5. Published

    Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

    Hall, S. R., Rasmussen, S. A., Crittenden, E., Dawson, C. A., Bartlett, K. E., Westhorpe, A. P., Albulescu, L-O., Kool, J., Gutiérrez, J. M. & Casewell, N. R., 14/12/2023, In: Nature Communications. 14, 1, p. 1-15 15 p., 7812.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Machine-learning guided Venom Induced Dermonecrosis Analysis tooL : VIDAL

    Laprade, W., Bartlett, K. E., Christensen, C. R., Kazandjian, T. D., Patel, R. N., Crittenden, E., Dawson, C. A., Mansourvar, M., Wolff, D. S., Fryer, T., Laustsen, A. H., Casewell, N. R., Gutiérrez, J. M., Hall, S. R. & Jenkins, T. P., 8/12/2023, In: Scientific Reports. 13, 1, 21662.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. 2022
  8. Published

    Proteomics and histological assessment of an organotypic model of human skin following exposure to Naja nigricollis venom

    Ahmadi, S., Pachis, S. T., Kalogeropoulos, K., McGeoghan, F., Canbay, V., Hall, S. R., Crittenden, E. P., Dawson, C. A., Bartlett, K. E., Gutiérrez, J. M., Casewell, N. R., Keller, U. A. D. & Laustsen, A. H., 31/12/2022, In: Toxicon. 220, 106955.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models

    McKeown, B. T., Relja, N. J., Hall, S. R., Gebremeskel, S., MacLeod, J. M., Veinotte, C. J., Bennett, L. G., Ohlund, L. B., Sleno, L., Jakeman, D. L., Berman, J. N., Johnston, B. & Goralski, K. B., 1/11/2022, In: Canadian journal of physiology and pharmacology. 100, 11, p. 1065-1076 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing

    Menzies, S. K., Litschka-Koen, T., Edge, R. J., Alsolaiss, J., Crittenden, E., Hall, S. R., Westhorpe, A., Thomas, B., Murray, J., Shongwe, N., Padidar, S., Lalloo, D. G., Casewell, N. R., Pons, J. & Harrison, R. A., 15/09/2022, In: PLoS Neglected Tropical Diseases. 16, 9, e0010496.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition

    Menzies, S. K., Dawson, C. A., Crittenden, E., Edge, R. J., Hall, S. R., Alsolaiss, J., Wilkinson, M. C., Casewell, N. R., Harrison, R. A. & Ainsworth, S., 5/07/2022, In: Scientific Reports. 12, 1, p. 11328

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms

    Alomran, N., Blundell, P., Alsolaiss, J., Crittenden, E., Ainsworth, S., Dawson, C. A., Edge, R. J., Hall, S. R., Harrison, R. A., Wilkinson, M. C., Menzies, S. K. & Casewell, N. R., 29/06/2022, In: Toxins. 14, 7, 443.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Physiological constraints dictate toxin spatial heterogeneity in snake venom glands

    Kazandjian, T. D., Hamilton, B. R., Robinson, S. D., Hall, S. R., Bartlett, K. E., Rowley, P., Wilkinson, M. C., Casewell, N. R. & Undheim, E. A. B., 27/06/2022, In: BMC Biology. 20, 1, 148.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus

    Menzies, S. K., Clare, R. H., Xie, C., Westhorpe, A., Hall, S. R., Edge, R. J., Alsolaiss, J., Crittenden, E., Marriott, A. E., Harrison, R. A., Kool, J. & Casewell, N. R., 18/03/2022, In: Toxicon: X. 14, p. 100118

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. 2021
  16. Published

    Small Molecule Drug Discovery for Neglected Tropical Snakebite

    Clare, R. H., Hall, S. R., Patel, R. N. & Casewell, N. R., 31/05/2021, In: Trends in Pharmacological Sciences. 42, 5, p. 340-353 14 p.

    Research output: Contribution to Journal/Magazine › Review article › peer-review

  17. 2020
  18. Published

    A Lipid-Based Oral Supplement Protects Skin Cells in Culture from Ultraviolet Light and Activates Antioxidant and Anti-Inflammatory Mechanisms

    Hall, S. R., Reid, A-J., Eng, J., McKeown, B. T., St-Onge, M. & Goralski, K. B., 22/06/2020, In: Journal of Natural Health Product Research. 2, 1, p. 1-14

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Decitabine Response in Breast Cancer Requires Efficient Drug Processing and Is Not Limited by Multidrug Resistance

    Dahn, M. L., Cruickshank, B. M., Jackson, A. J., Dean, C., Holloway, R. W., Hall, S., Coyle, K. M., Maillet, H., Waisman, D. M., Goralski, K. B., Giacomantonio, C. A., Weaver, I. C. G. & Marcato, P., 4/05/2020, In: Molecular Cancer Therapeutics. 19, 5, p. 1110–1122

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. 2019
  21. Published

    Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer

    Tomko, A., O'Leary, L., Trask, H., Achenbach, J. C., Hall, S. R., Goralski, K. B., Ellis, L. D. & Dupré, D. J., 27/09/2019, In: Frontiers in Pharmacology. 10, p. 1124

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. 2018
  23. Published

    The Anticancer Activity and Mechanisms of Action of Jadomycins in Multidrug Resistant Human Breast Cancer Cells

    Hall, S., 28/09/2018, 231 p.

    Research output: Thesis › Doctoral Thesis

  24. Published

    Isolation of a jadomycin incorporating L-ornithine, analysis of antimicrobial activity and jadomycin reactive oxygen species (ROS) generation in MDA-MB-231 breast cancer cells

    Forget, S. M., Robertson, A. W., Hall, S. R., MacLeod, J. M., Overy, D. P., Kerr, R. G., Goralski, K. B. & Jakeman, D. L., 26/04/2018, In: The Journal of antibiotics. 71, 8, p. 722-730 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    ZATT, TDP2, and SUMO2: Breaking the tie that binds TOP2 to DNA

    Hall, S. R. & Goralski, K. B., 26/04/2018, In: Translational Cancer Research. 7, 4, p. 1412-16

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Post Polyketide Synthase Carbon-Carbon Bond Formation in Type-II PKS-Derived Natural Products from Streptomyces venezuelae

    Robertson, A. W., MacLeod, J. M., MacIntyre, L. W., Forget, S. M., Hall, S. R., Bennett, L. G., Correa, H., Kerr, R. G., Goralski, K. B. & Jakeman, D. L., 16/02/2018, In: Journal of Organic Chemistry. 83, 4, p. 1876-1890 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. 2017
  28. Published

    Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells

    Hall, S. R., Toulany, J., Bennett, L. G., Martinez-Farina, C. F., Robertson, A. W., Jakeman, D. L. & Goralski, K. B., 1/11/2017, In: Journal of Pharmacology and Experimental Therapeutics. 363, 2, p. 196-210 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  29. 2015
  30. Published

    Jadomycin breast cancer cytotoxicity is mediated by a copper-dependent, reactive oxygen species-inducing mechanism

    Hall, S. R., Blundon, H. L., Ladda, M. A., Robertson, A. W., Martinez-Farina, C. F., Jakeman, D. L. & Goralski, K. B., 1/03/2015, In: Pharmacology research & perspectives. 3, 2, p. e00110

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. 2014
  32. Published

    Jadomycins are cytotoxic to ABCB1-, ABCC1-, and ABCG2-overexpressing MCF7 breast cancer cells

    Issa, M. E., Hall, S. R., Dupuis, S. N., Graham, C. L., Jakeman, D. L. & Goralski, K. B., 1/03/2014, In: Anti-Cancer Drugs. 25, 3, p. 255-69 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. 2013
  34. Published

    The synthesis and molecular structure of 1-(3,4-dihydroxyphenethyl)-3-hydroxy-2-methylpyridin-4(1H)-one hydrochloride methanol solvate

    Hall, S. R., Roy, R., McLaughlin, D. T., Sullivan, K. J., Barclay, R. C., Vogels, C. M., Decken, A. & Westcott, S. A., 17/05/2013, In: Crystals. 3, 2, p. 333-338 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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