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Small Molecule Drug Discovery for Neglected Tropical Snakebite

Research output: Contribution to Journal/MagazineReview articlepeer-review

<mark>Journal publication date</mark>31/05/2021
<mark>Journal</mark>Trends in Pharmacological Sciences
Issue number5
Number of pages14
Pages (from-to)340-353
Publication StatusPublished
Early online date15/04/21
<mark>Original language</mark>English


Snakebite envenoming is responsible for as many as 138 000 deaths annually, making it the world's most lethal neglected tropical disease (NTD). There is an urgent need to improve snakebite treatment, which currently relies on outdated and poorly tolerated biologic antivenoms that are often weakly efficacious, must be given intravenously in a healthcare setting, and are expensive to those who need them the most. Herein we describe the challenges associated with the discovery and development of new snakebite treatments and detail the great potential of venom toxin-inhibiting small molecule drugs. We finish by highlighting successful enabling strategies applied to other NTDs that could be exploited to facilitate the development of next-generation small molecule-based snakebite treatments.