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Professor Thomas Jaki

Formerly at Lancaster University

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  1. Published

    Analysing malaria drug trials on a per individual or a per clone basis: a comparison of methods

    Jaki, T., Parry, A., Winter, K. & Hastings, I., 30/07/2013, In: Statistics in Medicine. 32, 17, p. 3020-3038 19 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    An order restricted multi-arm multi-stage clinical trial design

    Serra, A., Mozgunov, P. & Jaki, T., 30/04/2022, In: Statistics in Medicine. 41, 9, p. 1613-1626 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. E-pub ahead of print

    An information-theoretic Phase I/II design for molecularly targeted agents that does not require an assumption of monotonicity

    Mozgunov, P. & Jaki, T. F., 15/06/2018, (E-pub ahead of print) In: Journal of the Royal Statistical Society: Series C (Applied Statistics). 68, 2, p. 347-367 21 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    An information-theoretic approach for selecting arms in clinical trials

    Mozgunov, P. & Jaki, T. F., 10/11/2020, In: Journal of the Royal Statistical Society: Series B (Statistical Methodology). 82, 5, p. 1223-1247 25 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    An alternative to traditional sample size determination for small patient populations

    Jackson, H. & Jaki, T., 3/07/2023, In: Statistics in Biopharmaceutical Research. 15, 3, p. 596-607 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    An alternative method to analyse the Biomarker-strategy design

    Kunz, C. U., Jaki, T. F. & Stallard, N., 30/12/2018, In: Statistics in Medicine. 37, 30, p. 4636-4651 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial

    UK NIHR Community, 19/06/2020, In: Trials. 21, 1, 3 p., 544.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter

    Griffiths, G. O., FitzGerald, R., Jaki, T., Corkhill, A., Reynolds, H., Ewings, S., Condie, S., Tilt, E., Johnson, L., Radford, M., Simpson, C., Saunders, G., Yeats, S., Mozgunov, P., Tansley-Hancock, O., Martin, K., Downs, N., Eberhart, I., Martin, J. W. B., Goncalves, C., & 18 othersSong, A., Fletcher, T., Byrne, K., Lalloo, D. G., Owen, A., Jacobs, M., Walker, L., Lyon, R., Woods, C., Gibney, J., Chiong, J., Chandiwana, N., Jacob, S., Lamorde, M., Orrell, C., Pirmohamed, M., Khoo, S. & investigators, O. B. O. T. AGILE., 26/07/2021, In: Trials. 22, 1, 5 p., 487.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs

    Burnett, T., Mozgunov, P., Pallmann, P., Villar, S. S., Wheeler, G. M. & Jaki, T., 19/11/2020, In: BMC Medicine. 18, 1, 21 p., 352.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Adaptive clinical trials in tuberculosis: applications, challenges and solutions

    Davis, G. R., Phillips, P. P. & Jaki, T., 1/06/2015, In: International Journal of Tuberculosis and Lung Disease. 19, 6, p. 626-634 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    A theoretical framework for estimation of AUCs in complete and incomplete sampling designs.

    Jaki, T. & Wolfsegger, M. J., 05/2009, In: Statistics in Biopharmaceutical Research. 1, 2, p. 176-184 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    A surface-free design for phase I dual-agent combination trials

    Mozgunov, P., Gasparini, M. & Jaki, T., 1/10/2020, In: Statistical Methods in Medical Research. 29, 10, p. 3093-3109 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    A review of the deterministic and diffusion approximations for stochastic chemical reaction networks

    Mozgunov, P., Beccuti, M., Horvath, A., Jaki, T. F., Sirovich, R. & Bibbona, E., 04/2018, In: Reaction Kinetics, Mechanisms and Catalysis. 123, 2, p. 289-312 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    A review of statistical updating methods for clinical prediction models

    Su, T-L., Jaki, T. F., Hickey, G., Buchan, I. & Sperrin, M., 1/01/2018, In: Statistical Methods in Medical Research. 27, 1, p. 185-197 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    A review of statistical designs for improving the efficiency of phase II studies in oncology

    Wason, J. & Jaki, T., 06/2016, In: Statistical Methods in Medical Research. 25, 3, p. 1010-1021 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis

    McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., Smyth, A. R., Smyth, R. L. & Pirmohamed, M., 4/02/2020, In: Scientific Reports. 10, 1, 9 p., 1796.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    A quantitative framework to inform extrapolation decisions in children

    Wadsworth, I., Hampson, L. V., Jaki, T., Sills, G. J., Marson, A. G. & Appleton, R., 1/02/2020, In: Journal of the Royal Statistical Society: Series A Statistics in Society. 183, 2, p. 515-534 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    A proposal for a new PhD level curriculum on quantitative methods for drug development

    Jaki, T. F., Gordon, A., Forster, P. S., Bijnens, L., Bornkamp, B., Brannath, W., Fontana, R., Gasparini, M., Hampson, L. V., Jacobs, T., Jones, B., Paoletti, X., Posch, M., Titman, A. C., Vonk, R. & Koenig, F., 09/2018, In: Pharmaceutical Statistics. 17, 5, p. 593-606 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data

    Cotterill, A., Lorand, D., Wang, J. & Jaki, T., 15/06/2015, In: Statistics in Medicine. 34, 13, p. 2138-2164 27 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    A permutation test for assessing the presence of individual differences in treatment effects

    Chang, C., Jaki, T., Sadiq, M. S., Kuhlemeier, A., Feaster, D., Cole, N., Lamont, A., Oberski, D., Desai, Y. & Lee Van Horn, M., 1/11/2021, In: Statistical Methods in Medical Research. 30, 11, p. 2369-2381 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule

    Barnett, H. Y., Villar, S. S., Geys, H. & Jaki, T., 31/03/2023, In: Biometrics. 79, 1, p. 86-97 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

    Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D., 15/08/2012, In: Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    A novel measure of drug benefit–risk assessment based on Scale Loss Score

    Saint-Hilary, G., Robert, V., Gasparini, M., Jaki, T. F. & Mozgunov, P., 1/09/2019, In: Statistical Methods in Medical Research. 28, 9, p. 2738-2753 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    A note on statistical analysis of organ weights in non-clinical toxicological studies.

    Wolfsegger, M. J., Jaki, T., Dietrich, B., Kunzler, J. A. & Barker, K., 10/2009, In: Toxicology and Applied Pharmacology. 240, 1, p. 117-122 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

    Wolfsegger, M. J., Gutjahr, G., Engl, W. & Jaki, T., 2014, In: Biometrics. 70, 1, p. 103-109 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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