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A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells. / Robinson, Iain M.; Burgoyne, Robert D.
In: FEBS Letters, Vol. 289, No. 2, 09.09.1991, p. 151-154.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Robinson, IM & Burgoyne, RD 1991, 'A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells', FEBS Letters, vol. 289, no. 2, pp. 151-154. https://doi.org/10.1016/0014-5793(91)81057-F

APA

Robinson, I. M., & Burgoyne, R. D. (1991). A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells. FEBS Letters, 289(2), 151-154. https://doi.org/10.1016/0014-5793(91)81057-F

Vancouver

Robinson IM, Burgoyne RD. A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells. FEBS Letters. 1991 Sept 9;289(2):151-154. doi: 10.1016/0014-5793(91)81057-F

Author

Robinson, Iain M. ; Burgoyne, Robert D. / A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells. In: FEBS Letters. 1991 ; Vol. 289, No. 2. pp. 151-154.

Bibtex

@article{6a0a8b93a3354b2781ee90a070053f5f,
title = "A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells",
abstract = "The fluorescent Ca2+ indicator Fura 2 was used to monitor Ca2+ release induced by the Ins(1,4,5)P3-mobilizing agonist angiotensin II (Ag II), caffeine and 2,5-di-(tert-butyl)-1,4-benzohydroquinone (tuBHQ), in intact bovine adrenal chromaffin cells. Under low external Ca2+ conditions, tuBHQ, Ag II and caffeine elicited Ca2+ rises, indicating Ca2+ release from internal stores. Prior addition of Ag II had no noticeable effect on the extent of release of Ca2+ induced by tuBHQ. Stimulation of the cells with tuBHQ before either Ag II or caffeine, similarly had no effect on Ca2+ released by these two agonists. It was concluded, therefore, that there is a third intracellular Ca2+ store in bovine adrenal chromaffin cells, distinct and non-overlapping, from those sensitive to caffeine or Ins(1,4,5)P3-Mobilizing agonists.",
keywords = "2,5-Di-(tert-butyl)-1,4-benzohydroquinone, Caffeine, Chromaffin cell, Inositol 1,4,5-trisphosphate, Intracellular Ca store",
author = "Robinson, {Iain M.} and Burgoyne, {Robert D.}",
year = "1991",
month = sep,
day = "9",
doi = "10.1016/0014-5793(91)81057-F",
language = "English",
volume = "289",
pages = "151--154",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - A distinct 2,5-di-(tert-butyl)-1,4-benzohydroquinone-sensitive calcium store in bovine adrenal chromaffin cells

AU - Robinson, Iain M.

AU - Burgoyne, Robert D.

PY - 1991/9/9

Y1 - 1991/9/9

N2 - The fluorescent Ca2+ indicator Fura 2 was used to monitor Ca2+ release induced by the Ins(1,4,5)P3-mobilizing agonist angiotensin II (Ag II), caffeine and 2,5-di-(tert-butyl)-1,4-benzohydroquinone (tuBHQ), in intact bovine adrenal chromaffin cells. Under low external Ca2+ conditions, tuBHQ, Ag II and caffeine elicited Ca2+ rises, indicating Ca2+ release from internal stores. Prior addition of Ag II had no noticeable effect on the extent of release of Ca2+ induced by tuBHQ. Stimulation of the cells with tuBHQ before either Ag II or caffeine, similarly had no effect on Ca2+ released by these two agonists. It was concluded, therefore, that there is a third intracellular Ca2+ store in bovine adrenal chromaffin cells, distinct and non-overlapping, from those sensitive to caffeine or Ins(1,4,5)P3-Mobilizing agonists.

AB - The fluorescent Ca2+ indicator Fura 2 was used to monitor Ca2+ release induced by the Ins(1,4,5)P3-mobilizing agonist angiotensin II (Ag II), caffeine and 2,5-di-(tert-butyl)-1,4-benzohydroquinone (tuBHQ), in intact bovine adrenal chromaffin cells. Under low external Ca2+ conditions, tuBHQ, Ag II and caffeine elicited Ca2+ rises, indicating Ca2+ release from internal stores. Prior addition of Ag II had no noticeable effect on the extent of release of Ca2+ induced by tuBHQ. Stimulation of the cells with tuBHQ before either Ag II or caffeine, similarly had no effect on Ca2+ released by these two agonists. It was concluded, therefore, that there is a third intracellular Ca2+ store in bovine adrenal chromaffin cells, distinct and non-overlapping, from those sensitive to caffeine or Ins(1,4,5)P3-Mobilizing agonists.

KW - 2,5-Di-(tert-butyl)-1,4-benzohydroquinone

KW - Caffeine

KW - Chromaffin cell

KW - Inositol 1,4,5-trisphosphate

KW - Intracellular Ca store

U2 - 10.1016/0014-5793(91)81057-F

DO - 10.1016/0014-5793(91)81057-F

M3 - Journal article

C2 - 1915840

AN - SCOPUS:0025868189

VL - 289

SP - 151

EP - 154

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 2

ER -