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A serially correlated gamma frailty model for longitudinal count data.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published
  • Robin; Henderson
  • Silvia Shimakura
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<mark>Journal publication date</mark>2003
<mark>Journal</mark>Biometrika
Issue number2
Volume90
Number of pages12
Pages (from-to)355-366
Publication StatusPublished
<mark>Original language</mark>English

Abstract

A Poisson-gamma model is introduced to account for between-subjects heterogeneity and within-subjects serial correlation occurring in longitudinal count data. The model extends the usual time-constant shared frailty approach to allow time-varying serially correlated gamma frailty whilst retaining standard marginal assumptions. A composite likelihood approach to estimation and testing for serial correlation is proposed. The work is motivated by a clinical trial on patient-controlled analgesia where the number of analgesic doses taken by hospital patients in successive time intervals following abdominal surgery is recorded.