Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - A serially correlated gamma frailty model for longitudinal count data.
AU - Henderson, Robin;
AU - Shimakura, Silvia
PY - 2003
Y1 - 2003
N2 - A Poisson-gamma model is introduced to account for between-subjects heterogeneity and within-subjects serial correlation occurring in longitudinal count data. The model extends the usual time-constant shared frailty approach to allow time-varying serially correlated gamma frailty whilst retaining standard marginal assumptions. A composite likelihood approach to estimation and testing for serial correlation is proposed. The work is motivated by a clinical trial on patient-controlled analgesia where the number of analgesic doses taken by hospital patients in successive time intervals following abdominal surgery is recorded.
AB - A Poisson-gamma model is introduced to account for between-subjects heterogeneity and within-subjects serial correlation occurring in longitudinal count data. The model extends the usual time-constant shared frailty approach to allow time-varying serially correlated gamma frailty whilst retaining standard marginal assumptions. A composite likelihood approach to estimation and testing for serial correlation is proposed. The work is motivated by a clinical trial on patient-controlled analgesia where the number of analgesic doses taken by hospital patients in successive time intervals following abdominal surgery is recorded.
KW - Composite likelihood
KW - Multivariate gamma distribution
KW - Patient-controlled analgesia
KW - Recurrent event data.
U2 - 10.1093/biomet/90.2.355
DO - 10.1093/biomet/90.2.355
M3 - Journal article
VL - 90
SP - 355
EP - 366
JO - Biometrika
JF - Biometrika
SN - 1464-3510
IS - 2
ER -