Home > Research > Publications & Outputs > Adult height, coronary heart disease and stroke

Associated organisational unit

Links

Text available via DOI:

View graph of relations

Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis

Research output: Contribution to journalJournal articlepeer-review

Published
  • EPIC-Netherland Investigators
  • UCLEB Investigators
  • IN Day
Close
<mark>Journal publication date</mark>12/2016
<mark>Journal</mark>International Journal of Epidemiology
Issue number6
Volume45
Number of pages11
Pages (from-to)1927-1937
Publication StatusPublished
Early online date15/05/15
<mark>Original language</mark>English

Abstract

Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D.Results: IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively],which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index (P