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Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis

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Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. / EPIC-Netherland Investigators; UCLEB Investigators; IN Day.
In: International Journal of Epidemiology, Vol. 45, No. 6, 12.2016, p. 1927-1937.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

EPIC-Netherland Investigators, UCLEB Investigators & IN Day 2016, 'Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis', International Journal of Epidemiology, vol. 45, no. 6, pp. 1927-1937. https://doi.org/10.1093/ije/dyv074

APA

EPIC-Netherland Investigators, UCLEB Investigators, & IN Day (2016). Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. International Journal of Epidemiology, 45(6), 1927-1937. https://doi.org/10.1093/ije/dyv074

Vancouver

EPIC-Netherland Investigators, UCLEB Investigators, IN Day. Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. International Journal of Epidemiology. 2016 Dec;45(6):1927-1937. Epub 2015 May 15. doi: 10.1093/ije/dyv074

Author

EPIC-Netherland Investigators ; UCLEB Investigators ; IN Day. / Adult height, coronary heart disease and stroke : a multi-locus Mendelian randomization meta-analysis. In: International Journal of Epidemiology. 2016 ; Vol. 45, No. 6. pp. 1927-1937.

Bibtex

@article{91bf01760dcd4bbeb06aa2059ef549cf,
title = "Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis",
abstract = "Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D.Results: IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively],which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index (P ",
author = "Eveline N{\"u}esch and Caroline Dale and Palmer, {Tom M.} and Jon White and Keating, {Brendan J.} and {van Iperen}, {Erik P. A.} and Anuj Goel and Sandosh Padmanabhan and Asselbergs, {Folkert W.} and {EPIC-Netherland Investigators} and Verschuren, {W. M.} and C. Wijmenga and {Van der Schouw}, {Y. T.} and Onland-Moret, {N. C.} and Lange, {Leslie A.} and Hovingh, {G. Kees} and Suthesh Sivapalaratnam and Morris, {Richard W.} and Whincup, {Peter H.} and Wannamethe, {Goya S.} and Gaunt, {Tom R.} and Shah Ebrahim and Laura Steel and Nikhil Nair and Reiner, {Alexander P.} and Charles Kooperberg and Wilson, {James F.} and Bolton, {Jennifer L.} and Stela McLachlan and Price, {Jacqueline F.} and Strachan, {Mark W. J.} and Robertson, {Christine M.} and Kleber, {Marcus E.} and Graciela Delgado and Winfried M{\"a}rz and Olle Melander and Dominiczak, {Anna F.} and Martin Farrall and Hugh Watkins and Maarten Leusink and {Maitland-van der Zee}, {Anke H.} and {de Groot}, {Mark C. H.} and Frank Dudbridge and Aroon Hingorani and Yoav Ben-Shlomo and Lawlor, {Debbie A.} and {UCLEB Investigators} and A. Amuzu and M. Caufield and A. Cavadino and J. Cooper and Davies, {T. L.} and {IN Day}",
year = "2016",
month = dec,
doi = "10.1093/ije/dyv074",
language = "English",
volume = "45",
pages = "1927--1937",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "NLM (Medline)",
number = "6",

}

RIS

TY - JOUR

T1 - Adult height, coronary heart disease and stroke

T2 - a multi-locus Mendelian randomization meta-analysis

AU - Nüesch, Eveline

AU - Dale, Caroline

AU - Palmer, Tom M.

AU - White, Jon

AU - Keating, Brendan J.

AU - van Iperen, Erik P. A.

AU - Goel, Anuj

AU - Padmanabhan, Sandosh

AU - Asselbergs, Folkert W.

AU - EPIC-Netherland Investigators

AU - Verschuren, W. M.

AU - Wijmenga, C.

AU - Van der Schouw, Y. T.

AU - Onland-Moret, N. C.

AU - Lange, Leslie A.

AU - Hovingh, G. Kees

AU - Sivapalaratnam, Suthesh

AU - Morris, Richard W.

AU - Whincup, Peter H.

AU - Wannamethe, Goya S.

AU - Gaunt, Tom R.

AU - Ebrahim, Shah

AU - Steel, Laura

AU - Nair, Nikhil

AU - Reiner, Alexander P.

AU - Kooperberg, Charles

AU - Wilson, James F.

AU - Bolton, Jennifer L.

AU - McLachlan, Stela

AU - Price, Jacqueline F.

AU - Strachan, Mark W. J.

AU - Robertson, Christine M.

AU - Kleber, Marcus E.

AU - Delgado, Graciela

AU - März, Winfried

AU - Melander, Olle

AU - Dominiczak, Anna F.

AU - Farrall, Martin

AU - Watkins, Hugh

AU - Leusink, Maarten

AU - Maitland-van der Zee, Anke H.

AU - de Groot, Mark C. H.

AU - Dudbridge, Frank

AU - Hingorani, Aroon

AU - Ben-Shlomo, Yoav

AU - Lawlor, Debbie A.

AU - UCLEB Investigators

AU - Amuzu, A.

AU - Caufield, M.

AU - Cavadino, A.

AU - Cooper, J.

AU - Davies, T. L.

AU - IN Day

PY - 2016/12

Y1 - 2016/12

N2 - Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D.Results: IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively],which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index (P 

AB - Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D.Results: IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively],which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index (P 

U2 - 10.1093/ije/dyv074

DO - 10.1093/ije/dyv074

M3 - Journal article

VL - 45

SP - 1927

EP - 1937

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 6

ER -