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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Aging affects the phase coherence between spontaneous oscillations in brain oxygenation and neural activity
AU - Bjerkan, Juliane
AU - Lancaster, Gemma
AU - Meglič, Bernard
AU - Kobal, Jan
AU - Crawford, Trevor J.
AU - McClintock, Peter V. E.
AU - Stefanovska, Aneta
PY - 2023/9/30
Y1 - 2023/9/30
N2 - The risk of neurodegenerative disorders increases with age, due to reduced vascular nutrition and impaired neuralfunction. However, the interactions between cardiovascular dynamics and neural activity, and how these interactionsevolve in healthy aging, are not well understood. Here, the interactions are studied by assessment of the phase coherencebetween spontaneous oscillations in cerebral oxygenation measured by fNIRS, the electrical activity of the brain measuredby EEG, and cardiovascular functions extracted from ECG and respiration effort, all simultaneously recorded. Signalsmeasured at rest in 21 younger participants (31.1±6.9 years) and 24 older participants (64.9±6.9 years) were analysedby wavelet transform, wavelet phase coherence and ridge extraction for frequencies between 0.007 and 4 Hz. Coherencebetween the neural and oxygenation oscillations at ∼0.1 Hz is significantly reduced in the older adults in 46/176 fNIRSEEGprobe combinations. This reduction in coherence cannot be accounted for in terms of reduced power, thus indicatingthat neurovascular interactions change with age. The approach presented promises a noninvasive means of evaluatingthe efficiency of the neurovascular unit in aging and disease.
AB - The risk of neurodegenerative disorders increases with age, due to reduced vascular nutrition and impaired neuralfunction. However, the interactions between cardiovascular dynamics and neural activity, and how these interactionsevolve in healthy aging, are not well understood. Here, the interactions are studied by assessment of the phase coherencebetween spontaneous oscillations in cerebral oxygenation measured by fNIRS, the electrical activity of the brain measuredby EEG, and cardiovascular functions extracted from ECG and respiration effort, all simultaneously recorded. Signalsmeasured at rest in 21 younger participants (31.1±6.9 years) and 24 older participants (64.9±6.9 years) were analysedby wavelet transform, wavelet phase coherence and ridge extraction for frequencies between 0.007 and 4 Hz. Coherencebetween the neural and oxygenation oscillations at ∼0.1 Hz is significantly reduced in the older adults in 46/176 fNIRSEEGprobe combinations. This reduction in coherence cannot be accounted for in terms of reduced power, thus indicatingthat neurovascular interactions change with age. The approach presented promises a noninvasive means of evaluatingthe efficiency of the neurovascular unit in aging and disease.
U2 - 10.1016/j.brainresbull.2023.110704
DO - 10.1016/j.brainresbull.2023.110704
M3 - Journal article
VL - 201
JO - Brain Research Bulletin
JF - Brain Research Bulletin
SN - 1873-2747
M1 - 110704
ER -