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Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila. / Razzaq, Azam; Robinson, Iain M.; McMahon, Harvey T. et al.
In: Genes and Development, Vol. 15, No. 22, 15.11.2001, p. 2967-2979.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Razzaq, A, Robinson, IM, McMahon, HT, Skepper, JN, Su, Y, Zelhof, AC, Jackson, AP, Gay, NJ & O'Kane, CJ 2001, 'Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila', Genes and Development, vol. 15, no. 22, pp. 2967-2979. https://doi.org/10.1101/gad.207801

APA

Razzaq, A., Robinson, I. M., McMahon, H. T., Skepper, J. N., Su, Y., Zelhof, A. C., Jackson, A. P., Gay, N. J., & O'Kane, C. J. (2001). Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila. Genes and Development, 15(22), 2967-2979. https://doi.org/10.1101/gad.207801

Vancouver

Razzaq A, Robinson IM, McMahon HT, Skepper JN, Su Y, Zelhof AC et al. Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila. Genes and Development. 2001 Nov 15;15(22):2967-2979. doi: 10.1101/gad.207801

Author

Razzaq, Azam ; Robinson, Iain M. ; McMahon, Harvey T. et al. / Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila. In: Genes and Development. 2001 ; Vol. 15, No. 22. pp. 2967-2979.

Bibtex

@article{8649627ecd5b486787fc351714cde200,
title = "Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila",
abstract = "Amphiphysins 1 and 2 are enriched in the mammalian brain and are proposed to recruit dynamin to sites of endocytosis. Shorter amphiphysin 2 splice variants are also found ubiquitously, with an enrichment in skeletal muscle. At the Drosophila larval neuromuscular junction, amphiphysin is localized postsynaptically and amphiphysin mutants have no major defects in neurotransmission; they are also viable, but flightless. Like mammalian amphiphysin 2 in muscles, Drosophila amphiphysin does not bind clathrin, but can tubulate lipids and is localized on T-tubules. Amphiphysin mutants have a novel phenotype, a severely disorganized T-tubule/sarcoplasmic reticulum system. We therefore propose that muscle amphiphysin is not involved in clathrin-mediated endocytosis, but in the structural organization of the membrane-bound compartments of the excitation-contraction coupling machinery of muscles.",
keywords = "DLG, Dynamin, Indirect flight muscles, Myopathy, Ryanodine receptor, T-tubules",
author = "Azam Razzaq and Robinson, {Iain M.} and McMahon, {Harvey T.} and Skepper, {Jeremy N.} and Ya Su and Zelhof, {Andrew C.} and Jackson, {Antony P.} and Gay, {Nicholas J.} and O'Kane, {Cahir J.}",
year = "2001",
month = nov,
day = "15",
doi = "10.1101/gad.207801",
language = "English",
volume = "15",
pages = "2967--2979",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "22",

}

RIS

TY - JOUR

T1 - Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila

AU - Razzaq, Azam

AU - Robinson, Iain M.

AU - McMahon, Harvey T.

AU - Skepper, Jeremy N.

AU - Su, Ya

AU - Zelhof, Andrew C.

AU - Jackson, Antony P.

AU - Gay, Nicholas J.

AU - O'Kane, Cahir J.

PY - 2001/11/15

Y1 - 2001/11/15

N2 - Amphiphysins 1 and 2 are enriched in the mammalian brain and are proposed to recruit dynamin to sites of endocytosis. Shorter amphiphysin 2 splice variants are also found ubiquitously, with an enrichment in skeletal muscle. At the Drosophila larval neuromuscular junction, amphiphysin is localized postsynaptically and amphiphysin mutants have no major defects in neurotransmission; they are also viable, but flightless. Like mammalian amphiphysin 2 in muscles, Drosophila amphiphysin does not bind clathrin, but can tubulate lipids and is localized on T-tubules. Amphiphysin mutants have a novel phenotype, a severely disorganized T-tubule/sarcoplasmic reticulum system. We therefore propose that muscle amphiphysin is not involved in clathrin-mediated endocytosis, but in the structural organization of the membrane-bound compartments of the excitation-contraction coupling machinery of muscles.

AB - Amphiphysins 1 and 2 are enriched in the mammalian brain and are proposed to recruit dynamin to sites of endocytosis. Shorter amphiphysin 2 splice variants are also found ubiquitously, with an enrichment in skeletal muscle. At the Drosophila larval neuromuscular junction, amphiphysin is localized postsynaptically and amphiphysin mutants have no major defects in neurotransmission; they are also viable, but flightless. Like mammalian amphiphysin 2 in muscles, Drosophila amphiphysin does not bind clathrin, but can tubulate lipids and is localized on T-tubules. Amphiphysin mutants have a novel phenotype, a severely disorganized T-tubule/sarcoplasmic reticulum system. We therefore propose that muscle amphiphysin is not involved in clathrin-mediated endocytosis, but in the structural organization of the membrane-bound compartments of the excitation-contraction coupling machinery of muscles.

KW - DLG

KW - Dynamin

KW - Indirect flight muscles

KW - Myopathy

KW - Ryanodine receptor

KW - T-tubules

U2 - 10.1101/gad.207801

DO - 10.1101/gad.207801

M3 - Journal article

C2 - 11711432

AN - SCOPUS:0035890136

VL - 15

SP - 2967

EP - 2979

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 22

ER -