Home > Research > Publications & Outputs > Applying evidence-based methods to the developm...

Electronic data

  • 2248-PDF-16755-1-10-20210420

    Rights statement: This work is licensed under a Creative Commons Attribution 4.0 International License. Articles are distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is appropriately cited (CC-BY). Copyright on any article in ALTEX is retained by the author(s).

    Final published version, 1.13 MB, PDF document

    Available under license: CC BY: Creative Commons Attribution 4.0 International License


Text available via DOI:

View graph of relations

Applying evidence-based methods to the development and use of adverse outcome pathways

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • R.B.M. de Vries
  • M. Angrish
  • P. Browne
  • J. Brozek
  • A.A. Rooney
  • D.S. Wikoff
  • S.W. Edwards
  • R.L. Morgan
  • I.L. Druwe
  • S. Hoffmann
  • T. Hartung
  • K. Thayer
  • M.T. Avey
  • B.E.J. Beverly
  • M. Falavigna
  • C. Gibbons
  • K. Goyak
  • A. Kraft
  • F. Nampo
  • A. Qaseem
  • M. Sears
  • J.A. Singh
  • C. Willett
  • E.Y. Yost
  • H. Schünemann
  • K. Tsaioun
<mark>Journal publication date</mark>20/04/2021
Issue number2
Number of pages12
Pages (from-to)336-347
Publication StatusPublished
<mark>Original language</mark>English


The workshop “Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests” was organized by the Evidence-based Toxicology Collaboration and hosted by the Grading of Recommendations Assessment, Development and Evaluation Working Group on June 12, 2019. The purpose of the workshop was to bring together international regulatory bodies, risk assessors, academic scientists, and industry to explore how systematic review methods and the adverse outcome pathway framework could be combined to develop and use mechanistic test methods for predicting the toxicity of chemical substances in an evidence-based manner. The meeting covered the history of biological frameworks, the way adverse outcome pathways are currently developed, the basic principles of systematic methodology, including systematic reviews and evidence maps, and assessment of certainty in models, and adverse outcome pathways in particular. Specific topics were discussed via case studies in small break-out groups. The group concluded that adverse outcome pathways provide an important framework to support mechanism-based assessment in environmental health. The process of their development has a few challenges that could be addressed with systematic methods and automation tools. Addressing these challenges will increase the transparency of the evidence behind adverse outcome pathways and the consistency with which they are defined; this in turn will increase their value for supporting public health decisions. It was suggested to explore the details of applying systematic methods to adverse outcome pathway development in a series of case studies and workshops.