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Available under license: CC BY: Creative Commons Attribution 4.0 International License
Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Applying evidence-based methods to the development and use of adverse outcome pathways
AU - de Vries, R.B.M.
AU - Angrish, M.
AU - Browne, P.
AU - Brozek, J.
AU - Rooney, A.A.
AU - Wikoff, D.S.
AU - Whaley, P.
AU - Edwards, S.W.
AU - Morgan, R.L.
AU - Druwe, I.L.
AU - Hoffmann, S.
AU - Hartung, T.
AU - Thayer, K.
AU - Avey, M.T.
AU - Beverly, B.E.J.
AU - Falavigna, M.
AU - Gibbons, C.
AU - Goyak, K.
AU - Kraft, A.
AU - Nampo, F.
AU - Qaseem, A.
AU - Sears, M.
AU - Singh, J.A.
AU - Willett, C.
AU - Yost, E.Y.
AU - Schünemann, H.
AU - Tsaioun, K.
PY - 2021/4/20
Y1 - 2021/4/20
N2 - The workshop “Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests” was organized by the Evidence-based Toxicology Collaboration and hosted by the Grading of Recommendations Assessment, Development and Evaluation Working Group on June 12, 2019. The purpose of the workshop was to bring together international regulatory bodies, risk assessors, academic scientists, and industry to explore how systematic review methods and the adverse outcome pathway framework could be combined to develop and use mechanistic test methods for predicting the toxicity of chemical substances in an evidence-based manner. The meeting covered the history of biological frameworks, the way adverse outcome pathways are currently developed, the basic principles of systematic methodology, including systematic reviews and evidence maps, and assessment of certainty in models, and adverse outcome pathways in particular. Specific topics were discussed via case studies in small break-out groups. The group concluded that adverse outcome pathways provide an important framework to support mechanism-based assessment in environmental health. The process of their development has a few challenges that could be addressed with systematic methods and automation tools. Addressing these challenges will increase the transparency of the evidence behind adverse outcome pathways and the consistency with which they are defined; this in turn will increase their value for supporting public health decisions. It was suggested to explore the details of applying systematic methods to adverse outcome pathway development in a series of case studies and workshops.
AB - The workshop “Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests” was organized by the Evidence-based Toxicology Collaboration and hosted by the Grading of Recommendations Assessment, Development and Evaluation Working Group on June 12, 2019. The purpose of the workshop was to bring together international regulatory bodies, risk assessors, academic scientists, and industry to explore how systematic review methods and the adverse outcome pathway framework could be combined to develop and use mechanistic test methods for predicting the toxicity of chemical substances in an evidence-based manner. The meeting covered the history of biological frameworks, the way adverse outcome pathways are currently developed, the basic principles of systematic methodology, including systematic reviews and evidence maps, and assessment of certainty in models, and adverse outcome pathways in particular. Specific topics were discussed via case studies in small break-out groups. The group concluded that adverse outcome pathways provide an important framework to support mechanism-based assessment in environmental health. The process of their development has a few challenges that could be addressed with systematic methods and automation tools. Addressing these challenges will increase the transparency of the evidence behind adverse outcome pathways and the consistency with which they are defined; this in turn will increase their value for supporting public health decisions. It was suggested to explore the details of applying systematic methods to adverse outcome pathway development in a series of case studies and workshops.
KW - adverse outcome pathway
KW - automation
KW - conference paper
KW - environmental health
KW - human
KW - outcome assessment
KW - public health
KW - systematic review
KW - editorial
KW - risk assessment
U2 - 10.14573/altex.2101211
DO - 10.14573/altex.2101211
M3 - Journal article
VL - 38
SP - 336
EP - 347
JO - Altex
JF - Altex
SN - 1868-596X
IS - 2
ER -