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Assessing developmental outcomes of children from Kilifi, Kenya following prophylaxis for seizures in Cerebral Malaria

Research output: Contribution to journalJournal articlepeer-review

  • Amina Abubakar
  • Fons J. R. Van de Vijver
  • Sadik Mithwani
  • Elizabeth Obiero
  • Naomi Lewa
  • Simon Kenga
  • Khamis Katana
  • Penny Holding
<mark>Journal publication date</mark>05/2007
<mark>Journal</mark>Journal of Health Psychology
Issue number3
Number of pages19
Pages (from-to)412-430
Publication StatusPublished
<mark>Original language</mark>English


The purpose of the study was to develop a culture-informed measure of developmental outcome and to apply it to detect differences in developmental level between children with cerebral malaria enrolled in a clinical trial to control seizures during the acute phase of the illness. The instrument was administered to a sample of 180 children, three and 12 months after discharge from hospital. The measure demonstrated high internal consistency, good inter-observer reliability, age sensitivity and strong relations with parental report of child functioning. No association was found between performance, or change in performance, with the prophylactic regime administered. The results suggested that the use of Phenobarbital in controlling provoked seizures has no observable effect on cognitive function.