TY - JOUR

T1 - Associations of Nutritional and Social Exposures in Utero, Early, and Later Childhood with Cognitive, Motor, and Social-Emotional Development in Indonesia (OR10-03-19)

AU - Prado, Elizabeth

AU - Sebayang, Susy K

AU - Adawiyah, Siti R.

AU - Harefa, Benyamin

AU - Alcock, Katie

AU - Ullman, Michael T.

AU - Muadz, Husni

AU - Shankar, Anuraj H.

PY - 2019/6/13

Y1 - 2019/6/13

N2 - Objectives: To determine the association of biomedical and socioenvironmental risk factors during pregnancy, early, and later childhoodwith cognitive (IQ), motor, social-emotional (SE), and executivefunction (EF) at age 3.5 and 9–12 y in Indonesia.Methods: Children born to pregnant women enrolled in the Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT)in 2001–2004 participated in follow-up studies at age 3.5 y in 2006and 9–12 y in 2013. We assessed 359 children at both time pointsfor outcomes of IQ, motor, SE and EF. We also assessed predictorsof outcomes including biomedical risks (small for gestational age atbirth: SGA; height-for-age z-score: HAZ; and child hemoglobin: Hb)and socio-environmental risks (HOME Inventory; maternal depression:MD). We calculated the residuals of earlier risks predicting the laterscores, e.g., the residual of SGA at birth predicting HAZ at 3.5 y(rHAZ1), representing the deviation of HAZ at 3.5 y from the child’sexpected HAZ based on SGA. In Model 1, we entered SGA, representingin utero exposures. In Model 2, we added indicators at 3.5 y (rHAZ1, Hb,HOME, MD). In Model 3, we added indicators at 9–12 y (rHAZ2, rHb,rHOME, rMD) and the corresponding 3.5 y IQ, motor, SE, or EF scores.Results: The coefficients for outcomes at early and later time points(Figure 1) show that SGA was not associated with any scores. Early(3.5 y) childhood rHAZ1 was associated with early IQ, motor, and EF,but was not independently associated with later (9–12 y) IQ, motor,or EF. Later childhood rHAZ2 was not associated with any scores.Early childhood HOME was independently associated with both earlyand later IQ, motor, and EF, while later childhood rHOME was notassociated with any scores. Early Hb was not associated with any scoresand later rHb was associated with motor scores only. MD duringearly childhood and rMD during later childhood were independentlyassociated with later childhood SE.Conclusions: These findings support the importance of early andcontinual intervention throughout childhood to support healthy growthand even more importantly maternal mental health and nurturing homeenvironments. This is essential for longer-term IQ, motor, SE, and EF.

AB - Objectives: To determine the association of biomedical and socioenvironmental risk factors during pregnancy, early, and later childhoodwith cognitive (IQ), motor, social-emotional (SE), and executivefunction (EF) at age 3.5 and 9–12 y in Indonesia.Methods: Children born to pregnant women enrolled in the Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT)in 2001–2004 participated in follow-up studies at age 3.5 y in 2006and 9–12 y in 2013. We assessed 359 children at both time pointsfor outcomes of IQ, motor, SE and EF. We also assessed predictorsof outcomes including biomedical risks (small for gestational age atbirth: SGA; height-for-age z-score: HAZ; and child hemoglobin: Hb)and socio-environmental risks (HOME Inventory; maternal depression:MD). We calculated the residuals of earlier risks predicting the laterscores, e.g., the residual of SGA at birth predicting HAZ at 3.5 y(rHAZ1), representing the deviation of HAZ at 3.5 y from the child’sexpected HAZ based on SGA. In Model 1, we entered SGA, representingin utero exposures. In Model 2, we added indicators at 3.5 y (rHAZ1, Hb,HOME, MD). In Model 3, we added indicators at 9–12 y (rHAZ2, rHb,rHOME, rMD) and the corresponding 3.5 y IQ, motor, SE, or EF scores.Results: The coefficients for outcomes at early and later time points(Figure 1) show that SGA was not associated with any scores. Early(3.5 y) childhood rHAZ1 was associated with early IQ, motor, and EF,but was not independently associated with later (9–12 y) IQ, motor,or EF. Later childhood rHAZ2 was not associated with any scores.Early childhood HOME was independently associated with both earlyand later IQ, motor, and EF, while later childhood rHOME was notassociated with any scores. Early Hb was not associated with any scoresand later rHb was associated with motor scores only. MD duringearly childhood and rMD during later childhood were independentlyassociated with later childhood SE.Conclusions: These findings support the importance of early andcontinual intervention throughout childhood to support healthy growthand even more importantly maternal mental health and nurturing homeenvironments. This is essential for longer-term IQ, motor, SE, and EF.

U2 - 10.1093/cdn/nzz034.OR10-03-19

DO - 10.1093/cdn/nzz034.OR10-03-19

M3 - Meeting abstract

VL - 3

SP - 735

JO - Current Developments in Nutrition

JF - Current Developments in Nutrition

IS - Supplement 1

ER -