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  • Bayesian_clinical_trial_designs___Another_option.98997

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Bayesian clinical trial designs: another option for trauma trials?

Research output: Contribution to journalJournal articlepeer-review

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  • UK-REBOA Trial Investigators
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<mark>Journal publication date</mark>10/2017
<mark>Journal</mark>Journal of Trauma and Acute Care Surgery
Issue number4
Volume83
Number of pages6
Pages (from-to)736-741
Publication StatusPublished
Early online date8/07/17
<mark>Original language</mark>English

Abstract

Conducting clinical trials in trauma care is challenging. As new treatments become available, we are faced with the dilemma of how to confirm their effectiveness, and strengthen the evidence base. Randomized controlled trials are the gold standard, but target groups in trauma care are often small and specialized, making the classical approach to trial design difficult. Bayesian designs represent an innovative means of increasing trial efficiency, and conducting trials with more realistic sample sizes. This article examines the design of such trials, using the UK-REBOA Trial as an example.

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Copyright © 2017 Ovid Technologies, Inc. All Rights Reserved