Final published version
Licence: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Research output: Contribution to Journal/Magazine › Review article › peer-review
<mark>Journal publication date</mark> | 02/2018 |
---|---|
<mark>Journal</mark> | Current opinion in immunology |
Volume | 50 |
Number of pages | 5 |
Pages (from-to) | 9-13 |
Publication Status | Published |
Early online date | 5/11/17 |
<mark>Original language</mark> | English |
Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties: their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.