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Control of innate-like B cell location for compartmentalised IgM production

Research output: Contribution to journalReview articlepeer-review

Published
<mark>Journal publication date</mark>02/2018
<mark>Journal</mark>Current opinion in immunology
Volume50
Number of pages5
Pages (from-to)9-13
Publication StatusPublished
Early online date5/11/17
<mark>Original language</mark>English

Abstract

Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties: their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.