Final published version
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Research output: Contribution to Journal/Magazine › Review article › peer-review
Research output: Contribution to Journal/Magazine › Review article › peer-review
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TY - JOUR
T1 - Control of innate-like B cell location for compartmentalised IgM production
AU - Jackson-Jones, Lucy H
AU - Bénézech, Cécile
N1 - Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2018/2
Y1 - 2018/2
N2 - Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties: their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.
AB - Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties: their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.
U2 - 10.1016/j.coi.2017.10.006
DO - 10.1016/j.coi.2017.10.006
M3 - Review article
C2 - 29078198
VL - 50
SP - 9
EP - 13
JO - Current opinion in immunology
JF - Current opinion in immunology
SN - 0952-7915
ER -