This volume contains selected papers from the Open Conference on Computers in Education (OCCE 2021), organized by Working Group (WG) 3.4 of the IFIP Technical Committee 3: Education (TC3) and supported by its other working groups. The conference was run as a hybrid conference, and this event pioneered this form of practice for IFIP and TC3. The online facilities were all run from the host organization, and the onsite element was held in Tampere, Finland, from August 17–20, 2021, hosted and supported by the University of Tampere. The conference was open to researchers, policy makers, educators, and practitioners worldwide. The conference title, which was also selected as the book title, Digital Transformation of Education and Learning – Past, Present and Future, reflects the ongoing commitment to (and current interests in) research and practice in learning and technology that members of TC3 and its working groups have fostered over many years, and continue to nurture today.