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Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs.

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Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs. / Wolfsegger, Martin J.; Jaki, Thomas.
In: Journal of Pharmacokinetics and Pharmacodynamics, Vol. 32, No. 5-6, 12.2005, p. 757-766.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Wolfsegger, MJ & Jaki, T 2005, 'Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs.', Journal of Pharmacokinetics and Pharmacodynamics, vol. 32, no. 5-6, pp. 757-766. https://doi.org/10.1007/s10928-005-0044-0

APA

Wolfsegger, M. J., & Jaki, T. (2005). Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs. Journal of Pharmacokinetics and Pharmacodynamics, 32(5-6), 757-766. https://doi.org/10.1007/s10928-005-0044-0

Vancouver

Wolfsegger MJ, Jaki T. Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs. Journal of Pharmacokinetics and Pharmacodynamics. 2005 Dec;32(5-6):757-766. doi: 10.1007/s10928-005-0044-0

Author

Wolfsegger, Martin J. ; Jaki, Thomas. / Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs. In: Journal of Pharmacokinetics and Pharmacodynamics. 2005 ; Vol. 32, No. 5-6. pp. 757-766.

Bibtex

@article{a022e808c5444b2f92a964a45a06654d,
title = "Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs.",
abstract = "Nonclinical in vivo animal studies have to be completed before starting clinical studies of the pharmacokinetic behavior of a drug in humans. The drug exposure in animal studies is often measured by the area under the concentration time curve (AUC). The classical complete data design where each animal is sampled for analysis once per time point is usually only applicable for large animals. In the case of rats and mice, where blood sampling is restricted, the batch design or the serial sacrifice design need to be considered. In batch designs samples are taken more than once from each animal, but not at all time points. In serial sacrifice designs only one sample is taken from each animal. This paper presents an estimator for AUC from 0 to infinity in serial sacrifice designs, the corresponding variance and its asymptotic distribution.",
keywords = "AUC, bootstrap, confidence intervals, serial sacrifice design",
author = "Wolfsegger, {Martin J.} and Thomas Jaki",
note = "The original publication is available at www.springerlink.com",
year = "2005",
month = dec,
doi = "10.1007/s10928-005-0044-0",
language = "English",
volume = "32",
pages = "757--766",
journal = "Journal of Pharmacokinetics and Pharmacodynamics",
issn = "1573-8744",
publisher = "Springer New York",
number = "5-6",

}

RIS

TY - JOUR

T1 - Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs.

AU - Wolfsegger, Martin J.

AU - Jaki, Thomas

N1 - The original publication is available at www.springerlink.com

PY - 2005/12

Y1 - 2005/12

N2 - Nonclinical in vivo animal studies have to be completed before starting clinical studies of the pharmacokinetic behavior of a drug in humans. The drug exposure in animal studies is often measured by the area under the concentration time curve (AUC). The classical complete data design where each animal is sampled for analysis once per time point is usually only applicable for large animals. In the case of rats and mice, where blood sampling is restricted, the batch design or the serial sacrifice design need to be considered. In batch designs samples are taken more than once from each animal, but not at all time points. In serial sacrifice designs only one sample is taken from each animal. This paper presents an estimator for AUC from 0 to infinity in serial sacrifice designs, the corresponding variance and its asymptotic distribution.

AB - Nonclinical in vivo animal studies have to be completed before starting clinical studies of the pharmacokinetic behavior of a drug in humans. The drug exposure in animal studies is often measured by the area under the concentration time curve (AUC). The classical complete data design where each animal is sampled for analysis once per time point is usually only applicable for large animals. In the case of rats and mice, where blood sampling is restricted, the batch design or the serial sacrifice design need to be considered. In batch designs samples are taken more than once from each animal, but not at all time points. In serial sacrifice designs only one sample is taken from each animal. This paper presents an estimator for AUC from 0 to infinity in serial sacrifice designs, the corresponding variance and its asymptotic distribution.

KW - AUC

KW - bootstrap

KW - confidence intervals

KW - serial sacrifice design

U2 - 10.1007/s10928-005-0044-0

DO - 10.1007/s10928-005-0044-0

M3 - Journal article

VL - 32

SP - 757

EP - 766

JO - Journal of Pharmacokinetics and Pharmacodynamics

JF - Journal of Pharmacokinetics and Pharmacodynamics

SN - 1573-8744

IS - 5-6

ER -