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    Rights statement: This is the author’s version of a work that was accepted for publication in Comparative Immunology, Microbiology and Infectious Diseases. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Comparative Immunology, Microbiology and Infectious Diseases, 77, 2021 DOI: 10.1016/j.cimid.2021.101670

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Immunogenicity and efficacy of a bivalent vaccine against infectious bronchitis virus

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Immunogenicity and efficacy of a bivalent vaccine against infectious bronchitis virus. / Abdel-Sabour, M.A.; Rohaim, M.A.; Salman, O.J.A.; Abodalal, S.E.; Mohammad, F.F.; Madkour, M.S.; Abdel-Wanis, N.A.; Munir, M.

In: Comparative Immunology, Microbiology and Infectious Diseases, Vol. 77, 31.08.2021.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Abdel-Sabour, MA, Rohaim, MA, Salman, OJA, Abodalal, SE, Mohammad, FF, Madkour, MS, Abdel-Wanis, NA & Munir, M 2021, 'Immunogenicity and efficacy of a bivalent vaccine against infectious bronchitis virus', Comparative Immunology, Microbiology and Infectious Diseases, vol. 77. https://doi.org/10.1016/j.cimid.2021.101670

APA

Abdel-Sabour, M. A., Rohaim, M. A., Salman, O. J. A., Abodalal, S. E., Mohammad, F. F., Madkour, M. S., Abdel-Wanis, N. A., & Munir, M. (2021). Immunogenicity and efficacy of a bivalent vaccine against infectious bronchitis virus. Comparative Immunology, Microbiology and Infectious Diseases, 77. https://doi.org/10.1016/j.cimid.2021.101670

Vancouver

Abdel-Sabour MA, Rohaim MA, Salman OJA, Abodalal SE, Mohammad FF, Madkour MS et al. Immunogenicity and efficacy of a bivalent vaccine against infectious bronchitis virus. Comparative Immunology, Microbiology and Infectious Diseases. 2021 Aug 31;77. https://doi.org/10.1016/j.cimid.2021.101670

Author

Abdel-Sabour, M.A. ; Rohaim, M.A. ; Salman, O.J.A. ; Abodalal, S.E. ; Mohammad, F.F. ; Madkour, M.S. ; Abdel-Wanis, N.A. ; Munir, M. / Immunogenicity and efficacy of a bivalent vaccine against infectious bronchitis virus. In: Comparative Immunology, Microbiology and Infectious Diseases. 2021 ; Vol. 77.

Bibtex

@article{b9ff15e9d9cb49f9a47dfcec8d92b688,
title = "Immunogenicity and efficacy of a bivalent vaccine against infectious bronchitis virus",
abstract = "Infectious bronchitis (IB) is a highly contagious viral disease and is responsible for considerable economic losses in the poultry industry, worldwide. To mitigate the IB-associated losses, multiple vaccines are being applied in the sector with variable successes and thus necessitating the development of a potent vaccine to protect against the IB in the poultry. In the present study, we investigated a bivalent live attenuated vaccine consisting of IB virus (IBV) strain H120 (GI-1 lineage) and D274 (GI-12 lineage) to evaluate its protection against heterologous variant of IBV (GI-23 lineage) in chicken. Protection efficacy was evaluated based on the serology, clinical signs, survival rates, tracheal and kidney histopathology and the viral shedding. Results demonstrated that administering live H120 and D274 (named here Classivar{\textregistered}) vaccine in one day-old and 14 days-old provided 100 % protection. We observed a significant increase in the mean antibody titers, reduced virus shedding, and ameliorated histopathology lesions compared to routinely used vaccination regimes. These results revealed that usage of different IBV vaccines combination can successfully ameliorate the clinical outcome and pathology in vaccinated chicks especially after booster vaccination regime using Classivar{\textregistered}. In conclusions, our data indicate that Classivar{\textregistered} vaccine is safe in chicks and may serve as an effective vaccine against the threat posed by commonly circulating IBV strains in the poultry industry. ",
keywords = "Chickens, Egypt, GI-23 lineage, Infectious bronchitis, Protection",
author = "M.A. Abdel-Sabour and M.A. Rohaim and O.J.A. Salman and S.E. Abodalal and F.F. Mohammad and M.S. Madkour and N.A. Abdel-Wanis and M. Munir",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Comparative Immunology, Microbiology and Infectious Diseases. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Comparative Immunology, Microbiology and Infectious Diseases, 77, 2021 DOI: 10.1016/j.cimid.2021.101670 ",
year = "2021",
month = aug,
day = "31",
doi = "10.1016/j.cimid.2021.101670",
language = "English",
volume = "77",
journal = "Comparative Immunology, Microbiology and Infectious Diseases",
issn = "0147-9571",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Immunogenicity and efficacy of a bivalent vaccine against infectious bronchitis virus

AU - Abdel-Sabour, M.A.

AU - Rohaim, M.A.

AU - Salman, O.J.A.

AU - Abodalal, S.E.

AU - Mohammad, F.F.

AU - Madkour, M.S.

AU - Abdel-Wanis, N.A.

AU - Munir, M.

N1 - This is the author’s version of a work that was accepted for publication in Comparative Immunology, Microbiology and Infectious Diseases. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Comparative Immunology, Microbiology and Infectious Diseases, 77, 2021 DOI: 10.1016/j.cimid.2021.101670

PY - 2021/8/31

Y1 - 2021/8/31

N2 - Infectious bronchitis (IB) is a highly contagious viral disease and is responsible for considerable economic losses in the poultry industry, worldwide. To mitigate the IB-associated losses, multiple vaccines are being applied in the sector with variable successes and thus necessitating the development of a potent vaccine to protect against the IB in the poultry. In the present study, we investigated a bivalent live attenuated vaccine consisting of IB virus (IBV) strain H120 (GI-1 lineage) and D274 (GI-12 lineage) to evaluate its protection against heterologous variant of IBV (GI-23 lineage) in chicken. Protection efficacy was evaluated based on the serology, clinical signs, survival rates, tracheal and kidney histopathology and the viral shedding. Results demonstrated that administering live H120 and D274 (named here Classivar®) vaccine in one day-old and 14 days-old provided 100 % protection. We observed a significant increase in the mean antibody titers, reduced virus shedding, and ameliorated histopathology lesions compared to routinely used vaccination regimes. These results revealed that usage of different IBV vaccines combination can successfully ameliorate the clinical outcome and pathology in vaccinated chicks especially after booster vaccination regime using Classivar®. In conclusions, our data indicate that Classivar® vaccine is safe in chicks and may serve as an effective vaccine against the threat posed by commonly circulating IBV strains in the poultry industry.

AB - Infectious bronchitis (IB) is a highly contagious viral disease and is responsible for considerable economic losses in the poultry industry, worldwide. To mitigate the IB-associated losses, multiple vaccines are being applied in the sector with variable successes and thus necessitating the development of a potent vaccine to protect against the IB in the poultry. In the present study, we investigated a bivalent live attenuated vaccine consisting of IB virus (IBV) strain H120 (GI-1 lineage) and D274 (GI-12 lineage) to evaluate its protection against heterologous variant of IBV (GI-23 lineage) in chicken. Protection efficacy was evaluated based on the serology, clinical signs, survival rates, tracheal and kidney histopathology and the viral shedding. Results demonstrated that administering live H120 and D274 (named here Classivar®) vaccine in one day-old and 14 days-old provided 100 % protection. We observed a significant increase in the mean antibody titers, reduced virus shedding, and ameliorated histopathology lesions compared to routinely used vaccination regimes. These results revealed that usage of different IBV vaccines combination can successfully ameliorate the clinical outcome and pathology in vaccinated chicks especially after booster vaccination regime using Classivar®. In conclusions, our data indicate that Classivar® vaccine is safe in chicks and may serve as an effective vaccine against the threat posed by commonly circulating IBV strains in the poultry industry.

KW - Chickens

KW - Egypt

KW - GI-23 lineage

KW - Infectious bronchitis

KW - Protection

U2 - 10.1016/j.cimid.2021.101670

DO - 10.1016/j.cimid.2021.101670

M3 - Journal article

VL - 77

JO - Comparative Immunology, Microbiology and Infectious Diseases

JF - Comparative Immunology, Microbiology and Infectious Diseases

SN - 0147-9571

ER -