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Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity

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Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity. / Kuhlemeier, A.; Jaki, T.; Jimenez, E.Y. et al.
In: Journal of Behavioral Medicine, Vol. 45, No. 2, 30.04.2022, p. 211-226.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Kuhlemeier, A, Jaki, T, Jimenez, EY, Kong, AS, Gill, H, Chang, C, Resnicow, K, Wilson, DK & Van Horn, ML 2022, 'Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity', Journal of Behavioral Medicine, vol. 45, no. 2, pp. 211-226. https://doi.org/10.1007/s10865-021-00274-2

APA

Kuhlemeier, A., Jaki, T., Jimenez, E. Y., Kong, A. S., Gill, H., Chang, C., Resnicow, K., Wilson, D. K., & Van Horn, M. L. (2022). Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity. Journal of Behavioral Medicine, 45(2), 211-226. https://doi.org/10.1007/s10865-021-00274-2

Vancouver

Kuhlemeier A, Jaki T, Jimenez EY, Kong AS, Gill H, Chang C et al. Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity. Journal of Behavioral Medicine. 2022 Apr 30;45(2):211-226. Epub 2022 Jan 15. doi: 10.1007/s10865-021-00274-2

Author

Kuhlemeier, A. ; Jaki, T. ; Jimenez, E.Y. et al. / Individual differences in the effects of the ACTION-PAC intervention : an application of personalized medicine in the prevention and treatment of obesity. In: Journal of Behavioral Medicine. 2022 ; Vol. 45, No. 2. pp. 211-226.

Bibtex

@article{cbb5b34c2c51481cb49b4c1559889b7c,
title = "Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity",
abstract = "There is an increased interest in the use of personalized medicine approaches in the prevention or treatment of obesity, however, few studies have used these approaches to identify individual differences in treatment effects. The current study demonstrates the use of the predicted individual treatment effects framework to test for individual differences in the effects of the ACTION-PAC intervention, which targeted the treatment and prevention of obesity in a high school setting. We show how methods for personalized medicine can be used to test for significant individual differences in responses to an intervention and we discuss the potential and limitations of these methods. In our example, 25% of students in the preventive intervention, were predicted to have their BMI z-score reduced by 0.39 or greater, while at other end of the spectrum, 25% were predicted to have their BMI z-score increased by 0.09 or more. In this paper, we demonstrate and discuss the process of using methods for personalized medicine with interventions targeting adiposity and discuss the lessons learned from this application. Ultimately, these methods have the potential to be useful for clinicians and clients in choosing between treatment options, however they are limited in their ability to help researchers understand the mechanisms underlying these predictions. ",
keywords = "Individual treatment effects, Obesity prevention, Personalized medicine",
author = "A. Kuhlemeier and T. Jaki and E.Y. Jimenez and A.S. Kong and H. Gill and C. Chang and K. Resnicow and D.K. Wilson and {Van Horn}, M.L.",
note = "The final publication is available at Springer via http://dx.doi.org/10.1007/s10865-021-00274-2",
year = "2022",
month = apr,
day = "30",
doi = "10.1007/s10865-021-00274-2",
language = "English",
volume = "45",
pages = "211--226",
journal = "Journal of Behavioral Medicine",
issn = "0160-7715",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - Individual differences in the effects of the ACTION-PAC intervention

T2 - an application of personalized medicine in the prevention and treatment of obesity

AU - Kuhlemeier, A.

AU - Jaki, T.

AU - Jimenez, E.Y.

AU - Kong, A.S.

AU - Gill, H.

AU - Chang, C.

AU - Resnicow, K.

AU - Wilson, D.K.

AU - Van Horn, M.L.

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s10865-021-00274-2

PY - 2022/4/30

Y1 - 2022/4/30

N2 - There is an increased interest in the use of personalized medicine approaches in the prevention or treatment of obesity, however, few studies have used these approaches to identify individual differences in treatment effects. The current study demonstrates the use of the predicted individual treatment effects framework to test for individual differences in the effects of the ACTION-PAC intervention, which targeted the treatment and prevention of obesity in a high school setting. We show how methods for personalized medicine can be used to test for significant individual differences in responses to an intervention and we discuss the potential and limitations of these methods. In our example, 25% of students in the preventive intervention, were predicted to have their BMI z-score reduced by 0.39 or greater, while at other end of the spectrum, 25% were predicted to have their BMI z-score increased by 0.09 or more. In this paper, we demonstrate and discuss the process of using methods for personalized medicine with interventions targeting adiposity and discuss the lessons learned from this application. Ultimately, these methods have the potential to be useful for clinicians and clients in choosing between treatment options, however they are limited in their ability to help researchers understand the mechanisms underlying these predictions.

AB - There is an increased interest in the use of personalized medicine approaches in the prevention or treatment of obesity, however, few studies have used these approaches to identify individual differences in treatment effects. The current study demonstrates the use of the predicted individual treatment effects framework to test for individual differences in the effects of the ACTION-PAC intervention, which targeted the treatment and prevention of obesity in a high school setting. We show how methods for personalized medicine can be used to test for significant individual differences in responses to an intervention and we discuss the potential and limitations of these methods. In our example, 25% of students in the preventive intervention, were predicted to have their BMI z-score reduced by 0.39 or greater, while at other end of the spectrum, 25% were predicted to have their BMI z-score increased by 0.09 or more. In this paper, we demonstrate and discuss the process of using methods for personalized medicine with interventions targeting adiposity and discuss the lessons learned from this application. Ultimately, these methods have the potential to be useful for clinicians and clients in choosing between treatment options, however they are limited in their ability to help researchers understand the mechanisms underlying these predictions.

KW - Individual treatment effects

KW - Obesity prevention

KW - Personalized medicine

U2 - 10.1007/s10865-021-00274-2

DO - 10.1007/s10865-021-00274-2

M3 - Journal article

VL - 45

SP - 211

EP - 226

JO - Journal of Behavioral Medicine

JF - Journal of Behavioral Medicine

SN - 0160-7715

IS - 2

ER -