Final published version
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
}
TY - CHAP
T1 - Investigating the lymphatic drainage of the brain
T2 - Essential skills and tools
AU - Albargothy, Nazira J.
AU - Sharp, Matthew Macgregor
AU - Gatherer, Maureen
AU - Morris, Alan
AU - Weller, Roy O.
AU - Hawkes, Cheryl
AU - Carare, Roxana O.
PY - 2017/1/7
Y1 - 2017/1/7
N2 - In this chapter we describe in detail the surgical and imaging techniques employed for the study of the anatomical routes of drainage of cerebrospinal fluid (CSF) and interstitial fluid (ISF) from the brain. The types of tracers, sites of injection, and volumes injected are crucial. For example, when testing the drainage of ISF from the parenchyma, volumes larger than 0.5 μL result in spillage of ISF into the ventricular CSF.
AB - In this chapter we describe in detail the surgical and imaging techniques employed for the study of the anatomical routes of drainage of cerebrospinal fluid (CSF) and interstitial fluid (ISF) from the brain. The types of tracers, sites of injection, and volumes injected are crucial. For example, when testing the drainage of ISF from the parenchyma, volumes larger than 0.5 μL result in spillage of ISF into the ventricular CSF.
KW - Alzheimer’s disease
KW - Cerebrospinal fluid
KW - Cisterna magna injections
KW - Interstitial fluid
KW - Intraparenchymal stereotactic injections
KW - Mouse brain
KW - Perivascular lymphatic drainage
KW - Rodent perfusion
KW - Solute clearance
U2 - 10.1007/978-1-4939-6786-5_24
DO - 10.1007/978-1-4939-6786-5_24
M3 - Chapter
C2 - 28063056
AN - SCOPUS:85009775061
SN - 9781493967841
T3 - Methods in Molecular Biology
SP - 343
EP - 365
BT - Methods in Molecular Biology
PB - Humana Press Inc.
CY - New York
ER -