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Final published version
Research output: Contribution to Journal/Magazine › Journal article
Research output: Contribution to Journal/Magazine › Journal article
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TY - JOUR
T1 - Kinetic model of selectivity and conductivity of the KcsA filter
AU - Gibby, W. A. T.
AU - Luchinsky, D. G.
AU - Kaufman, Igor Khaimovich
AU - Ward, A.
AU - McClintock, P. V. E.
PY - 2017/4/11
Y1 - 2017/4/11
N2 - We introduce a self-consistent multi-species kinetic theory based on the structure of the narrow voltage-gated potassium channel. Transition rates depend on a complete energy spectrum with contributions including the dehydration amongst species, interaction with the dipolar charge of the filter and, bulk solution properties. It displays high selectivity between species coexisting with fast conductivity, and Coulomb blockade phenomena, and it fits well to data.
AB - We introduce a self-consistent multi-species kinetic theory based on the structure of the narrow voltage-gated potassium channel. Transition rates depend on a complete energy spectrum with contributions including the dehydration amongst species, interaction with the dipolar charge of the filter and, bulk solution properties. It displays high selectivity between species coexisting with fast conductivity, and Coulomb blockade phenomena, and it fits well to data.
KW - physics.bio-ph
M3 - Journal article
JO - arxiv.org
JF - arxiv.org
M1 - 1704.03267
ER -