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Measurement of [11C]CO2 in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [11C] acetate

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Publication date2011
Host publication2011 IEEE Nuclear Science Symposium and Medical Imaging Conference
Place of PublicationNew York
PublisherIEEE
Pages2397-2399
Number of pages3
ISBN (print)978-1-4673-0118-3
<mark>Original language</mark>English
EventIEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th International Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors - Valencia
Duration: 23/10/201129/10/2011

Conference

ConferenceIEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th International Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors
CityValencia
Period23/10/1129/10/11

Conference

ConferenceIEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th International Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors
CityValencia
Period23/10/1129/10/11

Abstract

A positron-sensitive, large window single-wire proportional counter was used for measurements of [11C]CO2 in exhaled air after i.v. injection of [11C] acetate. The performance of the proportional counter was studied using Geant4 and Garfield simulation tools as well as experimentally by injections of known amounts of radioactive gas into measuring volume. The proportional counter was found to be sensitive enough for measuring the low concentrations of [11C]CO2 in the air exhaled by patients after i.v. injection of an 11C-labelled radiopharmaceutical. The limit of detection was 200 Bq/L for [11C]CO2.