Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Measuring similarity and improving stability in biomarker identification methods applied to Fourier-transform infrared (FTIR) spectroscopy
AU - Trevisan, Julio
AU - Park, Juhyun
AU - Angelov, Plamen
AU - Ahmadzai, Abdullah
AU - Gajjar, Ketan
AU - Scott, Andrew D.
AU - Carmichael, Paul L.
AU - Martin, Frank
PY - 2014/4
Y1 - 2014/4
N2 - FTIR spectroscopy is a powerful diagnostic tool that can also derive biochemical signatures of a wide range of cellular materials, such as cytology, histology, live cells, and biofluids. However, while classification is a well-established subject, biomarker identification lacks standards and validation of its methods. Validation of biomarker identification methods is difficult because, unlike classification, there is usually no reference biomarker against which to test the biomarkers extracted by a method. Inthis paper, we propose a framework to assess and improve the stability of biomarkers derived by a method, and to compare biomarkers derived by different method set-ups and between different methods by means of a proposed “biomarkers similarity index”.
AB - FTIR spectroscopy is a powerful diagnostic tool that can also derive biochemical signatures of a wide range of cellular materials, such as cytology, histology, live cells, and biofluids. However, while classification is a well-established subject, biomarker identification lacks standards and validation of its methods. Validation of biomarker identification methods is difficult because, unlike classification, there is usually no reference biomarker against which to test the biomarkers extracted by a method. Inthis paper, we propose a framework to assess and improve the stability of biomarkers derived by a method, and to compare biomarkers derived by different method set-ups and between different methods by means of a proposed “biomarkers similarity index”.
KW - biomarkers
KW - classification
KW - data mining
KW - Fourier-transform infrared spectroscopy
KW - statistical data analysis
KW - validation studies
KW - biospectroscopy
KW - computational framework
U2 - 10.1002/jbio.201300190
DO - 10.1002/jbio.201300190
M3 - Journal article
VL - 7
SP - 254
EP - 265
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 3-4
ER -