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Measuring vision using innate behaviours in mice with intact and impaired retina function

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Measuring vision using innate behaviours in mice with intact and impaired retina function. / Storchi, Riccardo; Rodgers, Jessica; Gracey, Maille; Martial, Franck P; Wynne, Jonathan; Ryan, Sean; Twining, Carole J; Cootes, Timothy F; Killick, Rebecca; Lucas, Robert J.

In: Scientific Reports, Vol. 9, 10396, 17.07.2019.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Storchi, R, Rodgers, J, Gracey, M, Martial, FP, Wynne, J, Ryan, S, Twining, CJ, Cootes, TF, Killick, R & Lucas, RJ 2019, 'Measuring vision using innate behaviours in mice with intact and impaired retina function', Scientific Reports, vol. 9, 10396. https://doi.org/10.1038/s41598-019-46836-y

APA

Storchi, R., Rodgers, J., Gracey, M., Martial, F. P., Wynne, J., Ryan, S., Twining, C. J., Cootes, T. F., Killick, R., & Lucas, R. J. (2019). Measuring vision using innate behaviours in mice with intact and impaired retina function. Scientific Reports, 9, [10396]. https://doi.org/10.1038/s41598-019-46836-y

Vancouver

Storchi R, Rodgers J, Gracey M, Martial FP, Wynne J, Ryan S et al. Measuring vision using innate behaviours in mice with intact and impaired retina function. Scientific Reports. 2019 Jul 17;9. 10396. https://doi.org/10.1038/s41598-019-46836-y

Author

Storchi, Riccardo ; Rodgers, Jessica ; Gracey, Maille ; Martial, Franck P ; Wynne, Jonathan ; Ryan, Sean ; Twining, Carole J ; Cootes, Timothy F ; Killick, Rebecca ; Lucas, Robert J. / Measuring vision using innate behaviours in mice with intact and impaired retina function. In: Scientific Reports. 2019 ; Vol. 9.

Bibtex

@article{98cae6bd6817485c875983e4bc347fcf,
title = "Measuring vision using innate behaviours in mice with intact and impaired retina function",
abstract = "Measuring vision in rodents is a critical step for understanding vision, improving models of human disease, and developing therapies. Established behavioural tests for perceptual vision, such as the visual water task, rely on learning. The learning process, while effective for sighted animals, can be laborious and stressful in animals with impaired vision, requiring long periods of training. Current tests that that do not require training are based on sub-conscious, reflex responses (e.g. optokinetic nystagmus) that don't require involvement of visual cortex and higher order thalamic nuclei. A potential alternative for measuring vision relies on using visually guided innate defensive responses, such as escape or freeze, that involve cortical and thalamic circuits. In this study we address this possibility in mice with intact and degenerate retinas. We first develop automatic methods to detect behavioural responses based on high dimensional tracking and changepoint detection of behavioural time series. Using those methods, we show that visually guided innate responses can be elicited using parametisable stimuli, and applied to describing the limits of visual acuity in healthy animals and discriminating degrees of visual dysfunction in mouse models of retinal degeneration.",
author = "Riccardo Storchi and Jessica Rodgers and Maille Gracey and Martial, {Franck P} and Jonathan Wynne and Sean Ryan and Twining, {Carole J} and Cootes, {Timothy F} and Rebecca Killick and Lucas, {Robert J}",
year = "2019",
month = jul,
day = "17",
doi = "10.1038/s41598-019-46836-y",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Measuring vision using innate behaviours in mice with intact and impaired retina function

AU - Storchi, Riccardo

AU - Rodgers, Jessica

AU - Gracey, Maille

AU - Martial, Franck P

AU - Wynne, Jonathan

AU - Ryan, Sean

AU - Twining, Carole J

AU - Cootes, Timothy F

AU - Killick, Rebecca

AU - Lucas, Robert J

PY - 2019/7/17

Y1 - 2019/7/17

N2 - Measuring vision in rodents is a critical step for understanding vision, improving models of human disease, and developing therapies. Established behavioural tests for perceptual vision, such as the visual water task, rely on learning. The learning process, while effective for sighted animals, can be laborious and stressful in animals with impaired vision, requiring long periods of training. Current tests that that do not require training are based on sub-conscious, reflex responses (e.g. optokinetic nystagmus) that don't require involvement of visual cortex and higher order thalamic nuclei. A potential alternative for measuring vision relies on using visually guided innate defensive responses, such as escape or freeze, that involve cortical and thalamic circuits. In this study we address this possibility in mice with intact and degenerate retinas. We first develop automatic methods to detect behavioural responses based on high dimensional tracking and changepoint detection of behavioural time series. Using those methods, we show that visually guided innate responses can be elicited using parametisable stimuli, and applied to describing the limits of visual acuity in healthy animals and discriminating degrees of visual dysfunction in mouse models of retinal degeneration.

AB - Measuring vision in rodents is a critical step for understanding vision, improving models of human disease, and developing therapies. Established behavioural tests for perceptual vision, such as the visual water task, rely on learning. The learning process, while effective for sighted animals, can be laborious and stressful in animals with impaired vision, requiring long periods of training. Current tests that that do not require training are based on sub-conscious, reflex responses (e.g. optokinetic nystagmus) that don't require involvement of visual cortex and higher order thalamic nuclei. A potential alternative for measuring vision relies on using visually guided innate defensive responses, such as escape or freeze, that involve cortical and thalamic circuits. In this study we address this possibility in mice with intact and degenerate retinas. We first develop automatic methods to detect behavioural responses based on high dimensional tracking and changepoint detection of behavioural time series. Using those methods, we show that visually guided innate responses can be elicited using parametisable stimuli, and applied to describing the limits of visual acuity in healthy animals and discriminating degrees of visual dysfunction in mouse models of retinal degeneration.

U2 - 10.1038/s41598-019-46836-y

DO - 10.1038/s41598-019-46836-y

M3 - Journal article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 10396

ER -