Molecular Virology of Orthopoxviruses with Special Reference to Monkeypox Virus

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Molecular Virology of Orthopoxviruses with Special Reference to Monkeypox Virus. / Rohaim, Mohammed A ; Naggar, Rania F El ; Atasoy, Mustafa O et al.
Poxviruses. ed. / N. Rezaei. Cham: Springer, 2024. p. 111-124 (Advances in Experimental Medicine and Biology; Vol. 1451).

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

Harvard

Rohaim, MA , Naggar, RFE , Atasoy, MO & Munir, M 2024, Molecular Virology of Orthopoxviruses with Special Reference to Monkeypox Virus. in N Rezaei (ed.), Poxviruses. Advances in Experimental Medicine and Biology, vol. 1451, Springer, Cham, pp. 111-124. https://doi.org/10.1007/978-3-031-57165-7_7

APA

Rohaim, M. A., Naggar, R. F. E., Atasoy, M. O., & Munir, M. (2024). Molecular Virology of Orthopoxviruses with Special Reference to Monkeypox Virus. In N. Rezaei (Ed.), Poxviruses (pp. 111-124). (Advances in Experimental Medicine and Biology; Vol. 1451). Springer. https://doi.org/10.1007/978-3-031-57165-7_7

Vancouver

Rohaim MA , Naggar RFE , Atasoy MO , Munir M. Molecular Virology of Orthopoxviruses with Special Reference to Monkeypox Virus. In Rezaei N, editor, Poxviruses. Cham: Springer. 2024. p. 111-124. (Advances in Experimental Medicine and Biology). doi: 10.1007/978-3-031-57165-7_7

Author

Rohaim, Mohammed A ; Naggar, Rania F El ; Atasoy, Mustafa O et al. / Molecular Virology of Orthopoxviruses with Special Reference to Monkeypox Virus. Poxviruses. editor / N. Rezaei. Cham : Springer, 2024. pp. 111-124 (Advances in Experimental Medicine and Biology).

Bibtex

@inbook{28537ac3988349bba47e8a1c2a9b25f8,

title = "Molecular Virology of Orthopoxviruses with Special Reference to Monkeypox Virus",

abstract = "Poxviruses are large (200-450 nm) and enveloped viruses carrying double-stranded DNA genome with an epidermal cell-specific adaptation. The genus Orthopoxvirus within Poxviridae family constitutes several medically and veterinary important viruses including variola (smallpox), vaccinia, monkeypox virus (MPXV), and cowpox. The monkeypox disease (mpox) has recently emerged as a public health emergency caused by MPXV. An increasing number of human cases of MPXV have been documented in non-endemic nations without any known history of contact with animals brought in from endemic and enzootic regions, nor have they involved travel to an area where the virus was typically prevalent. Here, we review the MPXV replication, virus pathobiology, mechanism of viral infection transmission, virus evasion the host innate immunity and antiviral therapies against Mpox. Moreover, preventive measures including vaccination were discussed and concluded that cross-protection against MPXV may be possible using antibodies that are directed against an Orthopoxvirus. Despite the lack of a specialised antiviral medication, several compounds such as Cidofovir and Ribavirin warrant consideration against mpox.",

keywords = "Humans, Animals, Monkeypox virus/genetics, Orthopoxvirus/genetics, Mpox (monkeypox)/virology, Antiviral Agents/therapeutic use, Virus Replication, Poxviridae Infections/virology",

author = "Rohaim, {Mohammed A} and Naggar, {Rania F El} and Atasoy, {Mustafa O} and Muhammad Munir",

note = "{\textcopyright} 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.",

year = "2024",

month = may,

day = "28",

doi = "10.1007/978-3-031-57165-7_7",

language = "English",

isbn = "9783031571640",

series = "Advances in Experimental Medicine and Biology",

publisher = "Springer",

pages = "111--124",

editor = "N. Rezaei",

booktitle = "Poxviruses",

}

RIS

TY - CHAP

T1 - Molecular Virology of Orthopoxviruses with Special Reference to Monkeypox Virus

AU - Rohaim, Mohammed A

AU - Naggar, Rania F El

AU - Atasoy, Mustafa O

AU - Munir, Muhammad

PY - 2024/5/28

Y1 - 2024/5/28

N2 - Poxviruses are large (200-450 nm) and enveloped viruses carrying double-stranded DNA genome with an epidermal cell-specific adaptation. The genus Orthopoxvirus within Poxviridae family constitutes several medically and veterinary important viruses including variola (smallpox), vaccinia, monkeypox virus (MPXV), and cowpox. The monkeypox disease (mpox) has recently emerged as a public health emergency caused by MPXV. An increasing number of human cases of MPXV have been documented in non-endemic nations without any known history of contact with animals brought in from endemic and enzootic regions, nor have they involved travel to an area where the virus was typically prevalent. Here, we review the MPXV replication, virus pathobiology, mechanism of viral infection transmission, virus evasion the host innate immunity and antiviral therapies against Mpox. Moreover, preventive measures including vaccination were discussed and concluded that cross-protection against MPXV may be possible using antibodies that are directed against an Orthopoxvirus. Despite the lack of a specialised antiviral medication, several compounds such as Cidofovir and Ribavirin warrant consideration against mpox.

AB - Poxviruses are large (200-450 nm) and enveloped viruses carrying double-stranded DNA genome with an epidermal cell-specific adaptation. The genus Orthopoxvirus within Poxviridae family constitutes several medically and veterinary important viruses including variola (smallpox), vaccinia, monkeypox virus (MPXV), and cowpox. The monkeypox disease (mpox) has recently emerged as a public health emergency caused by MPXV. An increasing number of human cases of MPXV have been documented in non-endemic nations without any known history of contact with animals brought in from endemic and enzootic regions, nor have they involved travel to an area where the virus was typically prevalent. Here, we review the MPXV replication, virus pathobiology, mechanism of viral infection transmission, virus evasion the host innate immunity and antiviral therapies against Mpox. Moreover, preventive measures including vaccination were discussed and concluded that cross-protection against MPXV may be possible using antibodies that are directed against an Orthopoxvirus. Despite the lack of a specialised antiviral medication, several compounds such as Cidofovir and Ribavirin warrant consideration against mpox.

KW - Humans

KW - Animals

KW - Monkeypox virus/genetics

KW - Orthopoxvirus/genetics

KW - Mpox (monkeypox)/virology

KW - Antiviral Agents/therapeutic use

KW - Virus Replication

KW - Poxviridae Infections/virology

U2 - 10.1007/978-3-031-57165-7_7

DO - 10.1007/978-3-031-57165-7_7

M3 - Chapter

C2 - 38801574

SN - 9783031571640

T3 - Advances in Experimental Medicine and Biology

SP - 111

EP - 124

BT - Poxviruses

A2 - Rezaei, N.

PB - Springer

CY - Cham

ER -

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