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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Multi-arm clinical trials with treatment selection
T2 - what can be gained and at what price?
AU - Jaki, Thomas
N1 - This work is licensed under the Creative Commons Attribution-NonCommercial 3.0 Unported License
PY - 2015/4
Y1 - 2015/4
N2 - With current success rates of confirmatory studies being only around 50%, new approaches to drug development are paramount. Many trials fail simply because ineffective treatments are identified too late. In this paper, we discuss the utility of multi-arm studies with treatment selection as a potential strategy that can reduce the high attrition rate. We illustrate the large gains in efficiency that are possible based on an example in Alzheimer's disease while outlining the additional challenges that need to be overcome to implement such studies.
AB - With current success rates of confirmatory studies being only around 50%, new approaches to drug development are paramount. Many trials fail simply because ineffective treatments are identified too late. In this paper, we discuss the utility of multi-arm studies with treatment selection as a potential strategy that can reduce the high attrition rate. We illustrate the large gains in efficiency that are possible based on an example in Alzheimer's disease while outlining the additional challenges that need to be overcome to implement such studies.
KW - adaptive design
KW - clinical trial design
KW - multi-arm multi-stage trials
KW - multi-arm trials
KW - treatment selection
U2 - 10.4155/cli.15.13
DO - 10.4155/cli.15.13
M3 - Journal article
VL - 5
SP - 393
EP - 399
JO - Clinical Investigation
JF - Clinical Investigation
SN - 2041-6792
IS - 4
ER -