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Myths and Methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Myths and Methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research. / Wrench, Elizabeth; Subar, Daren A.; Bampouras, Theodoros M. et al.
In: Experimental Physiology, Vol. 109, No. 9, 30.08.2024, p. 1461-1477.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Wrench, E, Subar, DA, Bampouras, TM, Lauder, B & Gaffney, CJ 2024, 'Myths and Methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research', Experimental Physiology, vol. 109, no. 9, pp. 1461-1477. https://doi.org/10.1113/EP091433

APA

Wrench, E., Subar, D. A., Bampouras, T. M., Lauder, B., & Gaffney, C. J. (2024). Myths and Methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research. Experimental Physiology, 109(9), 1461-1477. https://doi.org/10.1113/EP091433

Vancouver

Wrench E, Subar DA, Bampouras TM, Lauder B, Gaffney CJ. Myths and Methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research. Experimental Physiology. 2024 Aug 30;109(9):1461-1477. Epub 2024 Jul 16. doi: 10.1113/EP091433

Author

Wrench, Elizabeth ; Subar, Daren A. ; Bampouras, Theodoros M. et al. / Myths and Methodologies : Assessing glycaemic control and associated regulatory mechanisms in human physiology research. In: Experimental Physiology. 2024 ; Vol. 109, No. 9. pp. 1461-1477.

Bibtex

@article{0bb7cf88f8ef487683416f6503fa213d,
title = "Myths and Methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research",
abstract = "AbstractAccurate measurements of glycaemic control and the underpinning regulatory mechanisms are vital in human physiology research. Glycaemic control is the maintenance of blood glucose concentrations within optimal levels and is governed by physiological variables including insulin sensitivity, glucose tolerance and β‐cell function. These can be measured with a plethora of methods, all with their own benefits and limitations. Deciding on the best method to use is challenging and depends on the specific research question(s). This review therefore discusses the theory and procedure, validity and reliability and any special considerations of a range common methods used to measure glycaemic control, insulin sensitivity, glucose tolerance and β‐cell function. Methods reviewed include glycosylated haemoglobin, continuous glucose monitors, the oral glucose tolerance test, mixed meal tolerance test, hyperinsulinaemic euglycaemic clamp, hyperglycaemic clamp, intravenous glucose tolerance test and indices derived from both fasting concentrations and the oral glucose tolerance test. This review aims to help direct understanding, assessment and decisions regarding which method to use based on specific physiology‐related research questions.",
author = "Elizabeth Wrench and Subar, {Daren A.} and Bampouras, {Theodoros M.} and Bob Lauder and Gaffney, {Christopher J.}",
year = "2024",
month = aug,
day = "30",
doi = "10.1113/EP091433",
language = "English",
volume = "109",
pages = "1461--1477",
journal = "Experimental Physiology",
issn = "0958-0670",
publisher = "Wiley",
number = "9",

}

RIS

TY - JOUR

T1 - Myths and Methodologies

T2 - Assessing glycaemic control and associated regulatory mechanisms in human physiology research

AU - Wrench, Elizabeth

AU - Subar, Daren A.

AU - Bampouras, Theodoros M.

AU - Lauder, Bob

AU - Gaffney, Christopher J.

PY - 2024/8/30

Y1 - 2024/8/30

N2 - AbstractAccurate measurements of glycaemic control and the underpinning regulatory mechanisms are vital in human physiology research. Glycaemic control is the maintenance of blood glucose concentrations within optimal levels and is governed by physiological variables including insulin sensitivity, glucose tolerance and β‐cell function. These can be measured with a plethora of methods, all with their own benefits and limitations. Deciding on the best method to use is challenging and depends on the specific research question(s). This review therefore discusses the theory and procedure, validity and reliability and any special considerations of a range common methods used to measure glycaemic control, insulin sensitivity, glucose tolerance and β‐cell function. Methods reviewed include glycosylated haemoglobin, continuous glucose monitors, the oral glucose tolerance test, mixed meal tolerance test, hyperinsulinaemic euglycaemic clamp, hyperglycaemic clamp, intravenous glucose tolerance test and indices derived from both fasting concentrations and the oral glucose tolerance test. This review aims to help direct understanding, assessment and decisions regarding which method to use based on specific physiology‐related research questions.

AB - AbstractAccurate measurements of glycaemic control and the underpinning regulatory mechanisms are vital in human physiology research. Glycaemic control is the maintenance of blood glucose concentrations within optimal levels and is governed by physiological variables including insulin sensitivity, glucose tolerance and β‐cell function. These can be measured with a plethora of methods, all with their own benefits and limitations. Deciding on the best method to use is challenging and depends on the specific research question(s). This review therefore discusses the theory and procedure, validity and reliability and any special considerations of a range common methods used to measure glycaemic control, insulin sensitivity, glucose tolerance and β‐cell function. Methods reviewed include glycosylated haemoglobin, continuous glucose monitors, the oral glucose tolerance test, mixed meal tolerance test, hyperinsulinaemic euglycaemic clamp, hyperglycaemic clamp, intravenous glucose tolerance test and indices derived from both fasting concentrations and the oral glucose tolerance test. This review aims to help direct understanding, assessment and decisions regarding which method to use based on specific physiology‐related research questions.

U2 - 10.1113/EP091433

DO - 10.1113/EP091433

M3 - Journal article

C2 - 39014995

VL - 109

SP - 1461

EP - 1477

JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

IS - 9

ER -