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Non-equilibrium stochastic dynamics of open ion channels

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Non-equilibrium stochastic dynamics of open ion channels. / Tindjong, Rodrigue; Kaufman, Igor; Luchinsky, Dmitrii G. et al.
In: Nonlinear Phenomena in Complex Systems, Vol. 16, No. 2, 2013, p. 146-161.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Tindjong, R, Kaufman, I, Luchinsky, DG, McClintock, PVE, Khovanov, IA & Eisenberg, RS 2013, 'Non-equilibrium stochastic dynamics of open ion channels', Nonlinear Phenomena in Complex Systems, vol. 16, no. 2, pp. 146-161. <http://www.j-npcs.org/abstracts/vol2013/v16no2/v16no2p146.html>

APA

Tindjong, R., Kaufman, I., Luchinsky, D. G., McClintock, P. V. E., Khovanov, I. A., & Eisenberg, R. S. (2013). Non-equilibrium stochastic dynamics of open ion channels. Nonlinear Phenomena in Complex Systems, 16(2), 146-161. http://www.j-npcs.org/abstracts/vol2013/v16no2/v16no2p146.html

Vancouver

Tindjong R, Kaufman I, Luchinsky DG, McClintock PVE, Khovanov IA, Eisenberg RS. Non-equilibrium stochastic dynamics of open ion channels. Nonlinear Phenomena in Complex Systems. 2013;16(2):146-161.

Author

Tindjong, Rodrigue ; Kaufman, Igor ; Luchinsky, Dmitrii G. et al. / Non-equilibrium stochastic dynamics of open ion channels. In: Nonlinear Phenomena in Complex Systems. 2013 ; Vol. 16, No. 2. pp. 146-161.

Bibtex

@article{df1362ae64a742b2b440a2137062da72,
title = "Non-equilibrium stochastic dynamics of open ion channels",
abstract = "We present and discuss a modified version of reaction rate theory (RRT) to describe the passage of a positive ion through a biological ion channel. It takes explicit account of the non-equilibrium nature of the permeation process. Unlike traditional RRT, it allows for the non-constant transition rates that arise naturally in an archetypal model of an ion channel. In particular, we allow for the fact that the average escape time of an ion trapped at the selectivity filter (SF) can be reduced substantially by the pair correlations between ions: the arrival of a second ion at the channel entrance significantly reduces the potential barrier impeding the escape of the ion from the SF. The effects of this rate modulation on the current- voltage and current-concentration characteristics of the channel are studied parametrically. Stochastic amplification of the channel conductivity by charge fluctuations is demonstrated and compared with the results of Brownian dynamics simulations.",
keywords = "ion channels, permeation, nonequilibrium rate, stochastic dynamics, fluctuating barrier",
author = "Rodrigue Tindjong and Igor Kaufman and Luchinsky, {Dmitrii G.} and McClintock, {Peter V. E.} and Khovanov, {Igor A.} and Eisenberg, {R. S.}",
year = "2013",
language = "English",
volume = "16",
pages = "146--161",
journal = "Nonlinear Phenomena in Complex Systems",
issn = "1561-4085",
publisher = "Education and Upbringing Publishing",
number = "2",

}

RIS

TY - JOUR

T1 - Non-equilibrium stochastic dynamics of open ion channels

AU - Tindjong, Rodrigue

AU - Kaufman, Igor

AU - Luchinsky, Dmitrii G.

AU - McClintock, Peter V. E.

AU - Khovanov, Igor A.

AU - Eisenberg, R. S.

PY - 2013

Y1 - 2013

N2 - We present and discuss a modified version of reaction rate theory (RRT) to describe the passage of a positive ion through a biological ion channel. It takes explicit account of the non-equilibrium nature of the permeation process. Unlike traditional RRT, it allows for the non-constant transition rates that arise naturally in an archetypal model of an ion channel. In particular, we allow for the fact that the average escape time of an ion trapped at the selectivity filter (SF) can be reduced substantially by the pair correlations between ions: the arrival of a second ion at the channel entrance significantly reduces the potential barrier impeding the escape of the ion from the SF. The effects of this rate modulation on the current- voltage and current-concentration characteristics of the channel are studied parametrically. Stochastic amplification of the channel conductivity by charge fluctuations is demonstrated and compared with the results of Brownian dynamics simulations.

AB - We present and discuss a modified version of reaction rate theory (RRT) to describe the passage of a positive ion through a biological ion channel. It takes explicit account of the non-equilibrium nature of the permeation process. Unlike traditional RRT, it allows for the non-constant transition rates that arise naturally in an archetypal model of an ion channel. In particular, we allow for the fact that the average escape time of an ion trapped at the selectivity filter (SF) can be reduced substantially by the pair correlations between ions: the arrival of a second ion at the channel entrance significantly reduces the potential barrier impeding the escape of the ion from the SF. The effects of this rate modulation on the current- voltage and current-concentration characteristics of the channel are studied parametrically. Stochastic amplification of the channel conductivity by charge fluctuations is demonstrated and compared with the results of Brownian dynamics simulations.

KW - ion channels

KW - permeation

KW - nonequilibrium rate

KW - stochastic dynamics

KW - fluctuating barrier

M3 - Journal article

VL - 16

SP - 146

EP - 161

JO - Nonlinear Phenomena in Complex Systems

JF - Nonlinear Phenomena in Complex Systems

SN - 1561-4085

IS - 2

ER -