Home > Research > Publications & Outputs > Physics of selective conduction and point mutat...

Research

Associated organisational unit

Electronic data

  • PRLPaper

    Rights statement: © 2022 American Physical Society

    Accepted author manuscript, 1.68 MB, PDF document

    Available under license: CC BY: Creative Commons Attribution 4.0 International License

  • Supplementarty Material

    Accepted author manuscript, 3.37 MB, PDF document

    Available under license: CC BY: Creative Commons Attribution 4.0 International License

Links

Text available via DOI:

View graph of relations

Physics of selective conduction and point mutation in biological ion channels

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Physics of selective conduction and point mutation in biological ion channels. / Gibby, William A. T.; Barabash, Miraslau L.; Guardiani, Carlo et al.
In: Physical review letters, Vol. 126, No. 21, 218102, 28.05.2021.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gibby, WAT, Barabash, ML, Guardiani, C, Luchinsky, DG & McClintock, PVE 2021, 'Physics of selective conduction and point mutation in biological ion channels', Physical review letters, vol. 126, no. 21, 218102. https://doi.org/10.1103/PhysRevLett.126.218102

APA

Gibby, W. A. T., Barabash, M. L., Guardiani, C., Luchinsky, D. G., & McClintock, P. V. E. (2021). Physics of selective conduction and point mutation in biological ion channels. Physical review letters, 126(21), Article 218102. https://doi.org/10.1103/PhysRevLett.126.218102

Vancouver

Gibby WAT, Barabash ML, Guardiani C, Luchinsky DG, McClintock PVE. Physics of selective conduction and point mutation in biological ion channels. Physical review letters. 2021 May 28;126(21):218102. doi: 10.1103/PhysRevLett.126.218102

Author

Gibby, William A. T. ; Barabash, Miraslau L. ; Guardiani, Carlo et al. / Physics of selective conduction and point mutation in biological ion channels. In: Physical review letters. 2021 ; Vol. 126, No. 21.

Bibtex

@article{92739e6dd65d489e90c51340374e8866,
title = "Physics of selective conduction and point mutation in biological ion channels",
abstract = "We introduce a statistical and linear response theory of selective conduction in biological ion channels with multiple binding sites and possible point mutation. We derive an effective grand canonical ensemble and generalised Einstein relations for the selectivity filter, assuming strongly coordinated ionic motion, and allowing for ionic Coulomb blockade. The theory agrees well with data from the KcsA K+ channel and a mutant. We show that the Eisenman relations for thermodynamic selectivity follow from the condition for fast conduction and find that maximum conduction requires the binding sites to be nearly identical",
author = "Gibby, {William A. T.} and Barabash, {Miraslau L.} and Carlo Guardiani and Luchinsky, {Dmitry G.} and McClintock, {Peter V. E.}",
note = "{\textcopyright} 2022 American Physical Society ",
year = "2021",
month = may,
day = "28",
doi = "10.1103/PhysRevLett.126.218102",
language = "English",
volume = "126",
journal = "Physical review letters",
issn = "1079-7114",
publisher = "American Physical Society",
number = "21",

}

RIS

TY - JOUR

T1 - Physics of selective conduction and point mutation in biological ion channels

AU - Gibby, William A. T.

AU - Barabash, Miraslau L.

AU - Guardiani, Carlo

AU - Luchinsky, Dmitry G.

AU - McClintock, Peter V. E.

N1 - © 2022 American Physical Society

PY - 2021/5/28

Y1 - 2021/5/28

N2 - We introduce a statistical and linear response theory of selective conduction in biological ion channels with multiple binding sites and possible point mutation. We derive an effective grand canonical ensemble and generalised Einstein relations for the selectivity filter, assuming strongly coordinated ionic motion, and allowing for ionic Coulomb blockade. The theory agrees well with data from the KcsA K+ channel and a mutant. We show that the Eisenman relations for thermodynamic selectivity follow from the condition for fast conduction and find that maximum conduction requires the binding sites to be nearly identical

AB - We introduce a statistical and linear response theory of selective conduction in biological ion channels with multiple binding sites and possible point mutation. We derive an effective grand canonical ensemble and generalised Einstein relations for the selectivity filter, assuming strongly coordinated ionic motion, and allowing for ionic Coulomb blockade. The theory agrees well with data from the KcsA K+ channel and a mutant. We show that the Eisenman relations for thermodynamic selectivity follow from the condition for fast conduction and find that maximum conduction requires the binding sites to be nearly identical

U2 - 10.1103/PhysRevLett.126.218102

DO - 10.1103/PhysRevLett.126.218102

M3 - Journal article

VL - 126

JO - Physical review letters

JF - Physical review letters

SN - 1079-7114

IS - 21

M1 - 218102

ER -