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Polymer hydrogel-based microneedles for metformin release

Research output: Contribution to conference - Without ISBN/ISSN › Poster › peer-review

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Polymer hydrogel-based microneedles for metformin release. / Sharma, Manoj; Kap, Özlem; Abdelmohsen, Hend et al.
2022. Poster session presented at Recent Appointees in Materials Science 2022, Bradford, United Kingdom.

Research output: Contribution to conference - Without ISBN/ISSN › Poster › peer-review

Harvard

Sharma, M, Kap, Ö, Abdelmohsen, H, Harper, G, Firlak, M, Aaltonen, J, Bolland, K, Bragg, R, Deeley, S, Francis, E, Kazi, N, Mapley, B, Oikonomou, V, Aljohani, A, Halcovitch, N, Cheneler, D, Kılıç, V, Horzum, N & Hardy, J 2022, 'Polymer hydrogel-based microneedles for metformin release', Recent Appointees in Materials Science 2022, Bradford, United Kingdom, 5/09/22 - 6/09/22.

APA

Sharma, M., Kap, Ö., Abdelmohsen, H., Harper, G., Firlak, M., Aaltonen, J., Bolland, K., Bragg, R., Deeley, S., Francis, E., Kazi, N., Mapley, B., Oikonomou, V., Aljohani, A., Halcovitch, N., Cheneler, D., Kılıç, V., Horzum, N., & Hardy, J. (2022). Polymer hydrogel-based microneedles for metformin release. Poster session presented at Recent Appointees in Materials Science 2022, Bradford, United Kingdom.

Vancouver

Sharma M, Kap Ö, Abdelmohsen H, Harper G, Firlak M, Aaltonen J et al.. Polymer hydrogel-based microneedles for metformin release. 2022. Poster session presented at Recent Appointees in Materials Science 2022, Bradford, United Kingdom.

Author

Sharma, Manoj ; Kap, Özlem ; Abdelmohsen, Hend et al. / Polymer hydrogel-based microneedles for metformin release. Poster session presented at Recent Appointees in Materials Science 2022, Bradford, United Kingdom.

Bibtex

@conference{dd5c2e9fe0c8498599d4b9002e4c219c,
title = "Polymer hydrogel-based microneedles for metformin release",
abstract = "Drug delivery devices ensure the effective delivery of a broad range of therapeutics to millions of patients worldwide on a daily basis.1 Microneedles are a class of drug delivery device that provide pain free transdermal delivery with improved patient compliance.2-4 The release of metformin, a drug used in the treatment of cancer and diabetes, from polymer hydrogel-based microneedle patches was demonstrated in vitro. Tuning the composition of the polymer hydrogels enabled preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ca. 40 N). Swelling experiments conducted at 20°C, 35°C and 60°C show temperature dependent degrees of swelling and kinetics (Fickian diffusion). Drug release from the hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order, Korsmeyer-Peppas, Peppas-Sahlins), observing the best fit for the zero-order model. Such microneedles have potential application for transdermal delivery of metformin for the treatment of cancer and diabetes.",
author = "Manoj Sharma and {\"O}zlem Kap and Hend Abdelmohsen and Garry Harper and Melike Firlak and Jasmine Aaltonen and Kerry Bolland and Ryan Bragg and Sarah Deeley and Ella Francis and Nahin Kazi and Bethany Mapley and Vasileios Oikonomou and Amal Aljohani and Nathan Halcovitch and David Cheneler and Volkan Kılı{\c c} and Nesrin Horzum and John Hardy",
year = "2022",
month = sep,
day = "5",
language = "English",
note = "Recent Appointees in Materials Science 2022, RAMS2022 ; Conference date: 05-09-2022 Through 06-09-2022",
url = "https://ramsukcom.wordpress.com/",

}

RIS

TY - CONF

T1 - Polymer hydrogel-based microneedles for metformin release

AU - Sharma, Manoj

AU - Kap, Özlem

AU - Abdelmohsen, Hend

AU - Harper, Garry

AU - Firlak, Melike

AU - Aaltonen, Jasmine

AU - Bolland, Kerry

AU - Bragg, Ryan

AU - Deeley, Sarah

AU - Francis, Ella

AU - Kazi, Nahin

AU - Mapley, Bethany

AU - Oikonomou, Vasileios

AU - Aljohani, Amal

AU - Halcovitch, Nathan

AU - Cheneler, David

AU - Kılıç, Volkan

AU - Horzum, Nesrin

AU - Hardy, John

PY - 2022/9/5

Y1 - 2022/9/5

N2 - Drug delivery devices ensure the effective delivery of a broad range of therapeutics to millions of patients worldwide on a daily basis.1 Microneedles are a class of drug delivery device that provide pain free transdermal delivery with improved patient compliance.2-4 The release of metformin, a drug used in the treatment of cancer and diabetes, from polymer hydrogel-based microneedle patches was demonstrated in vitro. Tuning the composition of the polymer hydrogels enabled preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ca. 40 N). Swelling experiments conducted at 20°C, 35°C and 60°C show temperature dependent degrees of swelling and kinetics (Fickian diffusion). Drug release from the hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order, Korsmeyer-Peppas, Peppas-Sahlins), observing the best fit for the zero-order model. Such microneedles have potential application for transdermal delivery of metformin for the treatment of cancer and diabetes.

AB - Drug delivery devices ensure the effective delivery of a broad range of therapeutics to millions of patients worldwide on a daily basis.1 Microneedles are a class of drug delivery device that provide pain free transdermal delivery with improved patient compliance.2-4 The release of metformin, a drug used in the treatment of cancer and diabetes, from polymer hydrogel-based microneedle patches was demonstrated in vitro. Tuning the composition of the polymer hydrogels enabled preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ca. 40 N). Swelling experiments conducted at 20°C, 35°C and 60°C show temperature dependent degrees of swelling and kinetics (Fickian diffusion). Drug release from the hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order, Korsmeyer-Peppas, Peppas-Sahlins), observing the best fit for the zero-order model. Such microneedles have potential application for transdermal delivery of metformin for the treatment of cancer and diabetes.

M3 - Poster

T2 - Recent Appointees in Materials Science 2022

Y2 - 5 September 2022 through 6 September 2022

ER -