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Putative resolution of the EEEE selectivity paradox in L-type Ca2+ and bacterial Na+ biological ion channels

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Putative resolution of the EEEE selectivity paradox in L-type Ca2+ and bacterial Na+ biological ion channels. / Kaufman, Igor Kh; Luchinsky, Dmitrii Georgievich; Gibby, William A. T.; McClintock, Peter Vaughan Elsmere; Eisenberg, R. S.

In: Journal of Statistical Mechanics: Theory and Experiment, Vol. 2016, 054027 , 20.05.2016.

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@article{a2783d8f705d445c9ab9ee3c42111ed3,
title = "Putative resolution of the EEEE selectivity paradox in L-type Ca2+ and bacterial Na+ biological ion channels",
abstract = "The highly selective permeation of ions through biological ion channels can be described and explained in terms of fluctuational dynamics under the influence of powerful electrostatic forces. Hence valence selectivity, e.g. between Ca2+ and Na+ in calcium and sodium channels, can be described in terms of ionic Coulomb blockade, which gives rise to distinct conduction bands and stop-bands as the fixed negative charge Qf at the selectivity filter of the channel is varied. This picture accounts successfully for a wide range of conduction phenomena in a diversity of ion channels. A disturbing anomaly, however, is that what appears to be the same electrostatic charge and structure (the so-called EEEE motif) seems to select Na+ conduction in bacterial channels but Ca2+ conduction in mammalian channels. As a possible resolution of this paradox it is hypothesised that an additional charged protein residue on the permeation path of the mammalian channel increases |Qf | by e, thereby altering the selectivity from Na+ to Ca2+. Experiments are proposed that will enable the hypothesis to be tested.",
keywords = "Biological ion channels, Coulomb blockade, Stochastic dynamics, EEEE paradox, Brownian motion, stochastic processes (theory), dynamics (theory), diffusion",
author = "Kaufman, {Igor Kh} and Luchinsky, {Dmitrii Georgievich} and Gibby, {William A. T.} and McClintock, {Peter Vaughan Elsmere} and Eisenberg, {R. S.}",
year = "2016",
month = may,
day = "20",
doi = "10.1088/1742-5468/2016/05/054027",
language = "English",
volume = "2016",
journal = "Journal of Statistical Mechanics: Theory and Experiment",
issn = "1742-5468",
publisher = "IOP Publishing Ltd.",

}

RIS

TY - JOUR

T1 - Putative resolution of the EEEE selectivity paradox in L-type Ca2+ and bacterial Na+ biological ion channels

AU - Kaufman, Igor Kh

AU - Luchinsky, Dmitrii Georgievich

AU - Gibby, William A. T.

AU - McClintock, Peter Vaughan Elsmere

AU - Eisenberg, R. S.

PY - 2016/5/20

Y1 - 2016/5/20

N2 - The highly selective permeation of ions through biological ion channels can be described and explained in terms of fluctuational dynamics under the influence of powerful electrostatic forces. Hence valence selectivity, e.g. between Ca2+ and Na+ in calcium and sodium channels, can be described in terms of ionic Coulomb blockade, which gives rise to distinct conduction bands and stop-bands as the fixed negative charge Qf at the selectivity filter of the channel is varied. This picture accounts successfully for a wide range of conduction phenomena in a diversity of ion channels. A disturbing anomaly, however, is that what appears to be the same electrostatic charge and structure (the so-called EEEE motif) seems to select Na+ conduction in bacterial channels but Ca2+ conduction in mammalian channels. As a possible resolution of this paradox it is hypothesised that an additional charged protein residue on the permeation path of the mammalian channel increases |Qf | by e, thereby altering the selectivity from Na+ to Ca2+. Experiments are proposed that will enable the hypothesis to be tested.

AB - The highly selective permeation of ions through biological ion channels can be described and explained in terms of fluctuational dynamics under the influence of powerful electrostatic forces. Hence valence selectivity, e.g. between Ca2+ and Na+ in calcium and sodium channels, can be described in terms of ionic Coulomb blockade, which gives rise to distinct conduction bands and stop-bands as the fixed negative charge Qf at the selectivity filter of the channel is varied. This picture accounts successfully for a wide range of conduction phenomena in a diversity of ion channels. A disturbing anomaly, however, is that what appears to be the same electrostatic charge and structure (the so-called EEEE motif) seems to select Na+ conduction in bacterial channels but Ca2+ conduction in mammalian channels. As a possible resolution of this paradox it is hypothesised that an additional charged protein residue on the permeation path of the mammalian channel increases |Qf | by e, thereby altering the selectivity from Na+ to Ca2+. Experiments are proposed that will enable the hypothesis to be tested.

KW - Biological ion channels

KW - Coulomb blockade

KW - Stochastic dynamics

KW - EEEE paradox

KW - Brownian motion

KW - stochastic processes (theory)

KW - dynamics (theory)

KW - diffusion

U2 - 10.1088/1742-5468/2016/05/054027

DO - 10.1088/1742-5468/2016/05/054027

M3 - Journal article

VL - 2016

JO - Journal of Statistical Mechanics: Theory and Experiment

JF - Journal of Statistical Mechanics: Theory and Experiment

SN - 1742-5468

M1 - 054027

ER -