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    Rights statement: This is the peer reviewed version of the following article: Titman, A.C., Wolfsegger, M.J. and Jaki, T.F. (2021), Recurrent events modelling of haemophilia bleeding events. J R Stat Soc Series C, 70: 351-371. https://doi.org/10.1111/rssc.12462 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/rssc.12462 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

    Accepted author manuscript, 530 KB, PDF document

    Embargo ends: 7/01/22

    Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License

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Recurrent events modelling of haemophilia bleeding events

Research output: Contribution to journalJournal articlepeer-review

Published
<mark>Journal publication date</mark>31/03/2021
<mark>Journal</mark>Journal of the Royal Statistical Society: Series C (Applied Statistics)
Issue number2
Volume70
Number of pages21
Pages (from-to)351-371
Publication StatusPublished
Early online date7/01/21
<mark>Original language</mark>English

Abstract

A pharmacokinetic-pharmacodynamic (PK-PD) approach is developed for modelling recurrent bleeding events in patients with severe haemophilia to investigate the relationship between factor VIII plasma activity level and the instantaneous risk of a bleed. The model incorporates patient-level pharmacokinetic (PK) information obtained through measurements taken prior to the study which are used to fit a non-linear mixed effects two-compartment PK model. Dosing times within the study are combined with the PK model to provide the estimated factor VIII plasma level for all patients, which is used as a time dependent covariate within the recurrent events model. Methods are developed to correct the attenuation in covariate effects that would otherwise arise due to the discrepancy between estimated and true factor VIII. In contrast to existing methods proposed for such data, such as count data regression or time-to-event analysis, the new method allows all the bleeding times to be used to investigate the relationship between current factor VIII and risk of a bleed. The performance of the proposed estimators are assessed via simulation and found to outperform the naive estimator, which treats the estimated factor VIII levels as if they were measured without error, both in terms of bias and mean squared error.

Bibliographic note

This is the peer reviewed version of the following article: Titman, A.C., Wolfsegger, M.J. and Jaki, T.F. (2021), Recurrent events modelling of haemophilia bleeding events. J R Stat Soc Series C, 70: 351-371. https://doi.org/10.1111/rssc.12462 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/rssc.12462 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.