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Research output: Contribution to Journal/Magazine › Comment/debate
Research output: Contribution to Journal/Magazine › Comment/debate
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TY - JOUR
T1 - Regioselective silyl installation for arene diversification
AU - Docherty, Jamie
PY - 2025/4/25
Y1 - 2025/4/25
N2 - Using a single ruthenium catalyst, site-selective C–H functionalization methods are developed for the installation of silylmethyl synthetic handles at either ortho or meta positions on diverse arenes, enabling a wide range of downstream transformations. Mechanistic studies highlight that biscyclometallated ruthenium(II) species are key to this reactivity, offering insight for future developments.
AB - Using a single ruthenium catalyst, site-selective C–H functionalization methods are developed for the installation of silylmethyl synthetic handles at either ortho or meta positions on diverse arenes, enabling a wide range of downstream transformations. Mechanistic studies highlight that biscyclometallated ruthenium(II) species are key to this reactivity, offering insight for future developments.
U2 - 10.1038/s41929-025-01314-9
DO - 10.1038/s41929-025-01314-9
M3 - Comment/debate
VL - 8
SP - 291
EP - 292
JO - Nature Catalysis
JF - Nature Catalysis
ER -