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Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
}
TY - GEN
T1 - Relation between selectivity and conductivity in narrow ion channels
AU - Luchinsky, D. G.
AU - Gibby, W. A.T.
AU - Kaufman, I. Kh
AU - McClintock, P. V.E.
AU - Timucin, D. A.
N1 - ©2017 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
PY - 2017/7/19
Y1 - 2017/7/19
N2 - To establish the general statistical mechanical properties of highly conductive but selective nano-filters we develop an equilibrium statistical-mechanical theory of the KcsA filter, find the probabilities for the filter to bind ions from the mixed intra- and extra-cellular solutions, and evaluate the conductivity of the filter in its linear response regime. The results provide first principles analytical resolution of the long-standing paradox - how can narrow filter conduct potassium ions at nearly the rate of free diffusion while strongly selecting them over sodium ions - and are applicable to a wide range of biological and artificial channels.
AB - To establish the general statistical mechanical properties of highly conductive but selective nano-filters we develop an equilibrium statistical-mechanical theory of the KcsA filter, find the probabilities for the filter to bind ions from the mixed intra- and extra-cellular solutions, and evaluate the conductivity of the filter in its linear response regime. The results provide first principles analytical resolution of the long-standing paradox - how can narrow filter conduct potassium ions at nearly the rate of free diffusion while strongly selecting them over sodium ions - and are applicable to a wide range of biological and artificial channels.
KW - conductivity
KW - generalized Einstein relations
KW - grand canonical ensemble
KW - ion channel
KW - linear response
KW - selectivity
U2 - 10.1109/ICNF.2017.7985973
DO - 10.1109/ICNF.2017.7985973
M3 - Conference contribution/Paper
SN - 9781509027613
BT - 2017 International Conference on Noise and Fluctuations, ICNF 2017
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2017 International Conference on Noise and Fluctuations
Y2 - 20 June 2017 through 23 June 2017
ER -