Home > Research > Publications & Outputs > Replication dynamics of recombination-dependent...

Links

Text available via DOI:

View graph of relations

Replication dynamics of recombination-dependent replication forks

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published
Close
Article number923
<mark>Journal publication date</mark>10/02/2021
<mark>Journal</mark>Nature Communications
Issue number1
Volume12
Number of pages11
Publication StatusPublished
<mark>Original language</mark>English

Abstract

Replication forks restarted by homologous recombination are error prone and replicate both strands semi-conservatively using Pol δ. Here, we use polymerase usage sequencing to visualize in vivo replication dynamics of HR-restarted forks at an S. pombe replication barrier, RTS1, and model replication by Monte Carlo simulation. We show that HR-restarted forks synthesise both strands with Pol δ for up to 30 kb without maturing to a δ/ε configuration and that Pol α is not used significantly on either strand, suggesting the lagging strand template remains as a gap that is filled in by Pol δ later. We further demonstrate that HR-restarted forks progress uninterrupted through a fork barrier that arrests canonical forks. Finally, by manipulating lagging strand resection during HR-restart by deleting pku70, we show that the leading strand initiates replication at the same position, signifying the stability of the 3' single strand in the context of increased resection.