This book chapter looks to address how upcoming technology can be used to improve the efficiency of decommissioning processes within the nuclear industry. Challenges associated with decommissioning are introduced with a brief overview of the previous efforts and current practices of nuclear decommissioning. A high-level cyber-physical architecture for nuclear decommissioning applications is then proposed by drawing upon recent technological advances in the realm of Industry 4.0 such as internet of things, sensor networks, and increased use of data analytics and cloud computing approaches. In the final section, based on demands and proposals from industry, possible applications within the nuclear industry are identified and discussed.