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Sequence analysis and biological characterization of virulent Avian avulavirus 1 isolated from asymptomatic migratory fowl

Research output: Contribution to journalJournal articlepeer-review

E-pub ahead of print
  • Aziz Ul-Rahman
  • T Yaqub
  • M Imran
  • M Habib
  • T Sohail
  • N Mukhtar
  • M F Shahid
  • Muhammad Munir
  • M Z Shabbir
<mark>Journal publication date</mark>3/05/2019
<mark>Journal</mark>Acta virologica
Issue number2
Number of pages6
Pages (from-to)223-228
Publication StatusE-pub ahead of print
Early online date3/05/19
<mark>Original language</mark>English


Continuous monitoring and surveillance of avian avulaviruses (AAvVs) in water/migratory fowl is imperative to ascertain the evolutionary dynamics of these viruses. Here, we report genomic and amino acid characteristics of two AAvVs strains isolated from asymptomatic waterfowl (Anas carolinensis). Sequence characteristics including the presence of virulent motif (112RRQKR↓F117) and biological assessment confirmed the virulent nature of study isolates. Phylogenetic analysis of complete fusion (F) and hemagglutinin-neuraminidase (HN), and hyper-variable region of F gene revealed clustering of both strains within genotype VII and sub-genotype VIIi. The inferred residue analysis of complete F and HN genes revealed a number of substitutions in functionally and structurally important motif/s compared to reference strains of each genotype (I-XI). This study concludes an evolutionary nature of avian avulavaris 1 (AAvV-1), ascertaining continuous surveillance of migratory fowl to better elucidate their infection, epidemiology and subsequent impacts on commercial and backyard poultry. Keywords: virulent AAvV-1; migratory fowl; genetic characterization; evolutionary analysis; Pakistan.