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Simon’s minimax and optimal and Jung’s admissible two-stage design with or without curtailment

Research output: Contribution to journalJournal articlepeer-review

Published
<mark>Journal publication date</mark>2011
<mark>Journal</mark>Stata Journal
Issue number2
Volume11
Number of pages15
Pages (from-to)240-254
Publication StatusPublished
<mark>Original language</mark>English

Abstract

This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II oncology trials. Options are provided to determine the minimax and optimal designs proposed by Simon (1989, Controlled Clinical Trials 10: 1–10) and admissible designs described by Jung et al. (2004, Statistics in Medicine 23: 561–569). Furthermore, nonstochastic and stochastic curtailment rules can be implemented in both stages of the trial, and the properties of the curtailed designs can be examined.